(11)C-MK-8278 PET as a tool for pharmacodynamic brain occupancy of histamine 3 receptor inverse agonists.

@article{Laere201411CMK8278PA,
  title={(11)C-MK-8278 PET as a tool for pharmacodynamic brain occupancy of histamine 3 receptor inverse agonists.},
  author={Koen Van Laere and Sandra M. Sanabria-Boh{\'o}rquez and David P. Mozley and Donald H. Burns and Terence G. Hamill and Anne van Hecken and Inge de Lepeleire and Michel Koole and Guy Bormans and Jan N.J.M. de Hoon and Marleen Depr{\'e} and Kristine Cerchio and John Plalcza and Lingling Han and John Renger and Richard J. Hargreaves and Robert Iannone},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2014},
  volume={55 1},
  pages={
          65-72
        }
}
UNLABELLED The histamine 3 (H3) receptor is a presynaptic autoreceptor in the central nervous system that regulates the synthesis and release of histamine and modulates the release of other major neurotransmitters. H3 receptor inverse agonists (IAs) may be efficacious in the treatment of various central nervous system disorders, including excessive daytime sleepiness, attention deficit hyperactivity disorder, Alzheimer disease, ethanol addiction, and obesity. METHODS Using PET and a novel… CONTINUE READING
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