(-)-Nyasol (cis-hinokiresinol), a norneolignan from the rhizomes of Anemarrhena asphodeloides, is a broad spectrum inhibitor of eicosanoid and nitric oxide production

@article{Lim2009NyasolA,
  title={(-)-Nyasol (cis-hinokiresinol), a norneolignan from the rhizomes of Anemarrhena asphodeloides, is a broad spectrum inhibitor of eicosanoid and nitric oxide production},
  author={Hyun Joung Lim and Joo-Won Nam and Eun Kyoung Seo and Yeong Shik Kim and Hyun Pyo Kim},
  journal={Archives of Pharmacal Research},
  year={2009},
  volume={32},
  pages={1509-1514}
}
To assess the anti-inflammatory activity of constituents from the rhizomes of Anemarrhena asphodeloides, (-)-nyasol {cis-hinokiresinol, 4,4-[1Z,3R]-3-ethenyl-1-propene-1,3-diyl]bisphenol} was isolated and its anti-inflammatory activity was examined in lipopolysaccharide (LPS)-treated RAW 264.7 cells and A23187-treated RBL-1 cells. In vivo activity was measured using carrageenan-induced paw edema assay. At > 1 µM, (-)-nyasol significantly inhibited cyclooxygenase-2 (COX-2)-mediated PGE2… Expand
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