(-)-Epigallocatechin-3-gallate potentiates the cytotoxicity induced by benzyl isothiocyanate and hydrogen peroxide in human Jurkat T lymphocytes.

@article{Wu2008Epigallocatechin3gallatePT,
  title={(-)-Epigallocatechin-3-gallate potentiates the cytotoxicity induced by benzyl isothiocyanate and hydrogen peroxide in human Jurkat T lymphocytes.},
  author={Haitao Wu and Tomoko Yokoyama and Beiwei Zhu and Yasuaki Shimoishi and Yoshiyuki Murata and Yoshimasa Nakamura},
  journal={Bioscience, biotechnology, and biochemistry},
  year={2008},
  volume={72 11},
  pages={3034-7}
}
(-)-Epigallocatechin-3-gallate (EGCG)-induced apoptosis was along both the extracellular signal-regulated protein kinase (ERK) and c-jun N-terminal kinase (JNK) pathways in Jurkat cells. Co-treatment with EGCG potentiated the cytotoxicity induced by benzyl isothiocyanate (BITC) and H(2)O(2), both being inhibited by ERK and JNK inhibitors. These results suggest the significant role of mitogen-activated protein kinase (MAPK) signaling in the apoptosis induction regulated by EGCG alone and in… CONTINUE READING