(-)-Epigallocatechin-3-gallate downregulates Pg-P and BCRP in a tamoxifen resistant MCF-7 cell line.

@article{Farabegoli2010Epigallocatechin3gallateDP,
  title={(-)-Epigallocatechin-3-gallate downregulates Pg-P and BCRP in a tamoxifen resistant MCF-7 cell line.},
  author={F. Farabegoli and A. Papi and G. Bartolini and R. Ostan and M. Orlandi},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2010},
  volume={17 5},
  pages={
          356-62
        }
}
  • F. Farabegoli, A. Papi, +2 authors M. Orlandi
  • Published 2010
  • Biology, Medicine
  • Phytomedicine : international journal of phytotherapy and phytopharmacology
We investigated the anticancer effect of EGCG treatment on a breast carcinoma cell line resistant to tamoxifen (MCF-7Tam cells). As there are no reports about the molecular mechanisms implicated in EGCG treatment of tamoxifen resistant breast carcinoma cells, we studied the effects of EGCG treatment on three plasma membrane proteins that are involved in the mechanism of drug-resistance: Multidrug Resistance Protein (MRP1), P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP). EGCG… Expand
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