(−)‐Epigallocatechin gallate inhibits lipopolysaccharide‐induced microglial activation and protects against inflammation‐mediated dopaminergic neuronal injury

@article{Li2004EpigallocatechinGI,
  title={(−)‐Epigallocatechin gallate inhibits lipopolysaccharide‐induced microglial activation and protects against inflammation‐mediated dopaminergic neuronal injury},
  author={R. Li and Y. Huang and Du Fang and W. Le},
  journal={Journal of Neuroscience Research},
  year={2004},
  volume={78}
}
  • R. Li, Y. Huang, +1 author W. Le
  • Published 2004
  • Biology, Medicine
  • Journal of Neuroscience Research
Microglial activation is believed to play a pivotal role in the selective neuronal injury associated with several neurodegenerative disorders, including Parkinson's disease (PD) and Alzheimer's disease. We provide evidence that (−)‐epigallocatechin gallate (EGCG), a major monomer of green tea polyphenols, potently inhibits lipopolysaccharide (LPS)‐activated microglial secretion of nitric oxide (NO) and tumor necrosis factor‐α (TNF‐α) through the down‐regulation of inducible NO synthase and TNF… Expand
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