(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium

  title={(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium},
  author={Mar{\'i}a Bel{\'e}n Jim{\'e}nez-D{\'i}az and Daniel H. Ebert and Yandira G. Salinas and Anupam Pradhan and Adele M. Lehane and Marie-Eve Myrand-Lapierre and Kathleen G. O’Loughlin and David M Shackleford and Mariana Justino de Almeida and Angela K. Carrillo and Julie Clark and Adelaide S M Dennis and Jonathon Diep and Xiaoyan Deng and Sandra Duffy and Aaron N. Endsley and Greg Fedewa and Wendyam Armand Guiguemde and Mar{\'i}a G. G{\'o}mez and Gloria Holbrook and Jeremy A. Horst and Charles C. Kim and Jian Liu and Marcus C. S. Lee and Amy Matheny and Mar{\'i}a Santos Mart{\'i}nez and Gregory E. Miller and Ane Rodr{\'i}guez-Alejandre and Laura X Sanz and Martina Sigal and Natalie J Spillman and Philip D. Stein and Zheng Wang and Fangyi Zhu and David Waterson and Spencer Knapp and Anang A. Shelat and Vicky M. Avery and David A. Fidock and Francisco Javier Gamo and Susan A. Charman and Jon C. Mirsalis and Hongshen Ma and Santiago Ferrer and Kiaran Kirk and I{\~n}igo Angulo-Barturen and Dennis E. Kyle and Joseph L. Derisi and David Mack Floyd and R. Kiplin Guy},
  journal={Proceedings of the National Academy of Sciences},
  pages={E5455 - E5462}
Drug discovery for malaria has been transformed in the last 5 years by the discovery of many new lead compounds identified by phenotypic screening. [] Key Result Treatment of parasitized erythrocytes with (+)-SJ733 in vitro caused a rapid perturbation of Na(+) homeostasis in the parasite.

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