(+)-Fenfluramine and Its Major Metabolite, (+)-Norfenfluramine, Are Potent Substrates for Norepinephrine Transporters

  title={(+)-Fenfluramine and Its Major Metabolite, (+)-Norfenfluramine, Are Potent Substrates for Norepinephrine Transporters},
  author={R. Rothman and R. Clark and J. Partilla and M. Baumann},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={1191 - 1199}
  • R. Rothman, R. Clark, +1 author M. Baumann
  • Published 2003
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
  • (±)-Fenfluramine is an amphetamine analog that was once widely prescribed as an appetite suppressant. Although (±)-fenfluramine is no longer clinically available, the mechanisms underlying its anorectic properties are still of interest. Upon peripheral administration, stereoisomers of (±)-fenfluramine are N-deethylated to form the metabolites, (+)- and (-)-norfenfluramine. It is well accepted that isomers of (±)-fenfluramine and (±)-norfenfluramine interact with 5-hydroxytryptamine (serotonin… CONTINUE READING
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