'Wide-spectrum Ca2+ channel antagonists': lipophilicity, inhibition, and recovery of secretion in chromaffin cells.

@article{Lara1997WidespectrumCC,
  title={'Wide-spectrum Ca2+ channel antagonists': lipophilicity, inhibition, and recovery of secretion in chromaffin cells.},
  author={Baldomero Lara and Luis Gand{\'i}a and Andr{\'e}s Torres and Rom{\'a}n Olivares and Rafael Mart{\'i}nez-Sierra and A. G. Garcı́a and M. G. L{\'o}pez},
  journal={European journal of pharmacology},
  year={1997},
  volume={325 1},
  pages={
          109-19
        }
}
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The results suggest that dotarizine behaves as a Ca2+ antagonist in bovine chromaffin cells and exhibits a potency similar to flunarIZine in blocking Ca2- entry, Ca2+, channels, Cai2+ signals and secretion.
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All specific Ca++ antagonists interfere with the uptake of labelled Ca++ into the myocardium and prevent myocardial necrotization arising from deleterious intracellular Ca++ overload; they also block excitation-contraction coupling of vascular smooth muscle, and in this manner, lower Ca++-dependent coronary vascular tone and neutralize all types of experimental coronary spasms.
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