'Toxgnostics': an unmet need in cancer medicine

@article{Church2014ToxgnosticsAU,
  title={'Toxgnostics': an unmet need in cancer medicine},
  author={David N. Church and Rachel S Kerr and Enric Domingo and Dan Rosmarin and Claire Palles and Kevin F Maskell and Ian P. M. Tomlinson and David J Kerr},
  journal={Nature Reviews Cancer},
  year={2014},
  volume={14},
  pages={440-445}
}
If we were to summarize the rationale that underpins medical oncology in a Latin aphorism, it might be 'veneno ergo sum'; that is, I poison, therefore I am. The burden of chemotherapy-associated toxicity is well recognized, but we have relatively few tools that increase the precision of anticancer drug prescribing. We propose a shift in emphasis from the focussed study of polymorphisms in drug metabolic pathways in small sets of patients to broader agnostic analyses to systematically correlate… 
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28 Citations

Molecular and Functional Diagnostic Tools in Precision Oncology for Urological Malignancies
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Some of the recent developments in the area of molecular diagnostics and functional testing platforms and their potential application in clinical decision making in the premises of precision oncology of urological malignancies are captured.
High-throughput pharmacogenetics identifies SLCO1A2 polymorphisms as candidates to elucidate the risk of febrile neutropenia in the breast cancer RAPP-01 trial
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FN in patients receiving docetaxel in the RAPP-01 trial is significantly associated with the haplotype T–T in rs4762699 and rs2857468 in the SLCO1A2 transporter gene, which should be validated in an independent cohort.
Host genetic profiling to increase drug safety in colorectal cancer from discovery to implementation.
Clinical cancer research: the past, present and the future
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Four leading cancer researchers from around the world, and who have been associated with the journal since its launch in November 2004, are asked what they have learnt over the past 10 years and how the field should progress in the next 10 years.
The Quest for Evidence for Proton Therapy: Model-Based Approach and Precision Medicine.
Pharmaceutical Applications Based on Next Generation Sequencing Technology in Oncologic Drug Development
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This review aimed to provide information about the availability of next generation sequencing technology in pharmaceutical applications including areas such as tumor marker ÖZET.
“Pharmacogenetics of Cancer” - Cancer Drug Resistance special issue
© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted…
Pharmacogenetic biomarkers for chemotherapy-induced adverse drug reactions
TLDR
The use of harsh chemotherapies is motivated and accepted but, unfortunately, is often accompanied by side-effects that make it difficult to assess the effectiveness of these treatments.
Genomic foundation for medical and oral disease translation to clinical assessment
Prognostic markers for colorectal cancer: estimating ploidy and stroma
  • H. Danielsen, T. Hveem, D. Kerr
  • Medicine
    Annals of oncology : official journal of the European Society for Medical Oncology
  • 2018
TLDR
A novel biomarker, combining estimates of ploidy and stroma-tumour fraction, sampled from FFPE tissue, identifies stage II CRC patients with low, intermediate or high risk of CRC disease specific death, and can reliably stratify clinically relevant patient sub-populations with differential risks of tumour recurrence and may support choice of adjuvant therapy for these individuals.
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