'Toxgnostics': an unmet need in cancer medicine

  title={'Toxgnostics': an unmet need in cancer medicine},
  author={D. Church and R. Kerr and E. Domingo and Dan Rosmarin and C. Palles and K. Maskell and I. Tomlinson and D. Kerr},
  journal={Nature Reviews Cancer},
  • D. Church, R. Kerr, +5 authors D. Kerr
  • Published 2014
  • Medicine
  • Nature Reviews Cancer
  • If we were to summarize the rationale that underpins medical oncology in a Latin aphorism, it might be 'veneno ergo sum'; that is, I poison, therefore I am. The burden of chemotherapy-associated toxicity is well recognized, but we have relatively few tools that increase the precision of anticancer drug prescribing. We propose a shift in emphasis from the focussed study of polymorphisms in drug metabolic pathways in small sets of patients to broader agnostic analyses to systematically correlate… CONTINUE READING
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