• DOI:10.1038/nrc3729
Corpus ID: 21601547

'Toxgnostics': an unmet need in cancer medicine

@article{Church2014ToxgnosticsAU,
  title={'Toxgnostics': an unmet need in cancer medicine},
  author={D. Church and R. Kerr and E. Domingo and Dan Rosmarin and C. Palles and K. Maskell and I. Tomlinson and D. Kerr},
  journal={Nature Reviews Cancer},
  year={2014},
  volume={14},
  pages={440-445}
}

D. Church, R. Kerr, +5 authors D. Kerr

Published 2014

Medicine

Nature Reviews Cancer

If we were to summarize the rationale that underpins medical oncology in a Latin aphorism, it might be 'veneno ergo sum'; that is, I poison, therefore I am. The burden of chemotherapy-associated toxicity is well recognized, but we have relatively few tools that increase the precision of anticancer drug prescribing. We propose a shift in emphasis from the focussed study of polymorphisms in drug metabolic pathways in small sets of patients to broader agnostic analyses to systematically correlate… CONTINUE READING

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