'In vitro' interactions of monensin with hepatic xenobiotic metabolizing enzymes.

@article{Ceppa1997InVI,
  title={'In vitro' interactions of monensin with hepatic xenobiotic metabolizing enzymes.},
  author={L. Nebbia C. Ceppa and Mauro Dacasto and Monica Carletti and Clara Montesissa and C Nebbia},
  journal={Pharmacological research},
  year={1997},
  volume={36 3},
  pages={
          249-54
        }
}
Monensin, a polyether ionophore antibiotic used worldwide for its anticoccidial and growth-promoting properties, is reported to act as anin vivo inducer or inhibitor of drug-metabolizing enzyme systems in various species according to dosage regimens and duration of exposure. When incubated at a concentration up to 0.25 mM with hepatic subfractions from either untreated- (UT) or phenobarbital- (PB) induced rats, monensin did not induce appreciable changes in cytochrome P450 content and functions… CONTINUE READING
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