Corpus ID: 10726958

' ' Title Efficient synthesis of 3-trifluoromethylphenyldiazirinyl oleic acid derivatives and Their biological activity for protein kinase C

@inproceedings{Hashimoto2017T,
  title={' ' Title Efficient synthesis of 3-trifluoromethylphenyldiazirinyl oleic acid derivatives and Their biological activity for protein kinase C},
  author={Makoto Hashimoto and Kensuke Nabeta and Kentaro Murakami},
  year={2017}
}
3-Trifluoromethylphenyldiazirine based oleic acids derivatives are synthesized to elucidate the functions of specific activation of protein kinase C (PKC) with oleic acid. The synthetic route is based on the alkylation of phenolic derivative with oleic acid equivalent and the post–functionalization of the compound to achieve radiolabeling. Several compounds have biological activity for PKC with similar efficacy with that of oleic acid. The results indicated that the diaizinyl oleic acid… Expand

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