Corpus ID: 54191336

��inica� ��� and��chani��� o� In�i�i�a� �r�at��nt on In�a��ator� Bo��� �i��a��� A ��c�nt �pdat�

@inproceedings{Guo2013inicaA,
  title={��inica� ��� and��chani��� o� In�i�i�a� �r�at��nt on In�a��ator� Bo��� �i��a��� A ��c�nt �pdat�},
  author={Y. S. Guo and Nonghua Lu and Aiping Bai},
  year={2013}
}
e pathogenesis and treatment of in�ammatory bowel disease (IBD) have been recently advanced, while it is still challenged with high morbidity and poor prognosis. In�iximab, a monoclonal antibody of tumor necrosis factor (TNF), has emerged as an e�cient treatment with many clinical bene�ts such as quick disease activity reduction and IBD patient life quality improvement. However, the biological effects of in�iximab on IBD need to be elucidated. is paper reviewed the clinical use and recently… Expand

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References

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TLDR
A commentary on infection prophylaxis for the pediatric age group is presented to present a commentary on infections in pediatric IBD as well as the European Crohn's and Colitis Organization guidelines. Expand
Optimizing anti-TNF treatment in inflammatory bowel disease.
TLDR
Trial data suggest that systematic maintenance with 8 weekly doses of infliximab decreases the rate of complications, hospitalizations, and surgeries and these effects probably are achieved thanks to thorough healing of the bowel. Expand
Defective mucosal T cell death is sustainably reverted by infliximab in a caspase dependent pathway in Crohn’s disease
TLDR
It is demonstrated that apoptosis is the major mechanism by which infliximab exerts its killing activity on LPT in Crohn’s disease, and the sustained LPT proapoptotic action of inflIXimab, which extends far beyond its circulating half life, may be responsible for the sustained remission induced in Cro bowel disease patients by inflixIMab retreatment. Expand
Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease
TLDR
Inhibiting the proinflammatory cytokine tumor necrosis factor dramatically reduces gut inflammation and largely restores the gut barrier in Crohn's disease, confirming the central role of TNF in gut barrier modulation in inflammatory conditions in vivo. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
This is the first case of psoriasis induced first by infliximab and later by adalimumab in the same CD patient, and the reason for this apparently paradoxical effect of the therapy is still unclear. Expand
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TLDR
Treatment of IBD may include combination or sequential cytokine and anticytokine administration in defined groups of patients based on their mucosal cytokine profiles, and treatment with recombinant human interleukin-10 has been beneficial in Crohn's disease but not in ulcerative colitis. Expand
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