알쯔하이머 병의 분자 유전학

@inproceedings{2001,
  title={알쯔하이머 병의 분자 유전학},
  author={우성일 and 서한길},
  year={2001}
}
The sequencing of the amino acids in the β-amyloid and the cloning of the amyloid precursor protein(APP) gene were the breakthrough events in the molecular biologic researches about the Alzheimer's disease. After then, the mutations in the APP gene, presenilin 1 gene and presenilin 2 gene associated with the familial Alzheimer's disease(FAD) were found. Also, the roles of APOE e 4 as a risk allele and APOE e 2 as a protective allele in late onset AD, were demonstrated. All of the mutations… CONTINUE READING