„Natural”︁ killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Characteristics of the killer cell
@article{Kiessling1975NaturalKC, title={„Natural”︁ killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Characteristics of the killer cell}, author={Rolf Kiessling and Eva Klein and Hugh F. Pross and Hans Wigzell}, journal={European Journal of Immunology}, year={1975}, volume={5} }
Normal mice contain cytolytic cells with specificity for in vitro grown mouse Moloney leukemia cells. Such killer cells are most frequent in the spleens; lymph node and bone marrow contain less and thymus virtually no killer activity. Peak activity is found around one to three months of age. Spleen cells from genetically athymic mice are as active killer cells as those from normal mice of the same strain. Treatment with anti‐theta serum plus complement followed by removal of adherent and…
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„Natural”︁ killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype
- BiologyEuropean journal of immunology
- 1975
Analysis of the kinetics of the cytotoxic assay revealed a rapid induction of lysis within one to four hours, arguing against any conventional in vitro induction of immune response.
Transient killer cells mediating antibody-dependent cell cytotoxicity to chicken erythrocytes in mouse spleen during post natal development.
- Biology, MedicineDevelopmental and comparative immunology
- 1985
Natural cytotoxicity to human leukemia mediated by mouse non‐t cells
- Biology, MedicineInternational journal of cancer
- 1977
It is shown that mouse NK cells also function in a xenogeneic system, and unlabelled mouse T lymphoma YAC‐1 cells were efficient competitors for lysis of human T leukemia lines.
Killer cells: a functional comparison between natural, immune T-cell and antibody-dependent in vitro systems
- Biology, MedicineThe Journal of experimental medicine
- 1976
The present results further distinguish the NK cell from cytotoxic T lymphocytes or from antibody- dependent killer cells.
Inhibition of natural killer cell-mediated lysis of tumor cells by normal and regenerating bone marrow.
- Biology, MedicineImmunobiology
- 1988
Surface markers on natural killer cells of the mouse
- Biology, MedicineEuropean journal of immunology
- 1979
The results indicate that the absorbed anti‐BAT can distinguish NK cells from other known subsets of T and B cells.
Natural killer cell activity in reticulum‐cell sarcomas of SJL/J mice. II. Analysis of RCS‐associated NK activity
- Biology, MedicineInternational journal of cancer
- 1981
The data indicate that the RCS tumors represent either neoplastic expansion of conventional NK cells with somewhat modified properties, or else an entirely new class of cytotoxic effector cells.
Hybrid resistance to EL-4 lymphoma cells. I. Characterization of natural killer cells that lyse EL-4 cells and their distinction from marrow-dependent natural killer cells
- Biology, MedicineThe Journal of experimental medicine
- 1979
It is concluded that Hh-1b is the common antigen present in EL-4 and YAC-1 cells, because B6D2F1 anti-B6 (anti- Hh -1b) cytotoxic T lymphocytes lysed both the tumor cells.
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