„Field cancerization“ im oberen Aerodigestivtrakt

  title={„Field cancerization“ im oberen Aerodigestivtrakt},
  author={Hans Scher{\"u}bl and J. Steinberg and C. Schwertner and Parwis Mir-Salim and Ulrich St{\"o}lzel and Ethel Michele De Villiers},
ZusammenfassungDas Phänomen der multifokalen, syn- und metachronen Karzinogenese (bei stattgehabter Tabak- und oft auch Alkoholexposition) bezeichnete Slaughter 1953 als „field cancerization“ des oberen Aerodigestivtrakts. Patienten mit Kopf-Hals-Karzinomen tragen ein Risiko von 5–14%, an einem Plattenepithelzweitkarzinom der Speiseröhre oder der Bronchien zu erkranken. Die endoskopische Überwachung ermöglicht eine Früherkennung von ösophagealen Zweitneoplasien und eine frühe kurative Therapie… 
Prävalenz auffälliger Schleimhautbefunde bei Patienten in HNO-Praxen
It is simple and safe to examine patients at risk of developing HNSCC by standard HNO methods and the rate of detected carcinomas is much higher than in former investigations, likely because the survey focused only on patients with specific risk factors.
Intraepitheliale Plattenepithelneoplasie (WHO 2005)
The recent WHO classification 2005 applies the concept of intraepithelial neoplasia to the head and neck region and Precursor lesions of theHead and neck mucosa are classified as squamous intraepIthelial Neoplasia (SIN) and are graded as mild, moderate and severe (Sin 1–3).
Searching for metachronous tumours in patients with head and neck cancer: the ideal protocol!
It is now possible to review traditional follow-up policy for treated head and neck cancer patients, to encourage the implementation of an evidence-based surveillance protocol and to incorporate modern targeted expensive tumour screening and to allow treatment of early cancer and effective treatment, thereby improving patients' quality of life and increasing survival.
Incidence and localization of abnormal mucosa findings in patients consulting ENT outpatient clinics and data analysis of a cancer registry
For patients without symptoms and at risk, there is no established early detection program to discover carcinomas of the upper aerodigestive tract and the ratio of the found malignancies exceeds the expected ratio significantly, which presumably was caused by the examination targeting patients at risk.
Initial staging of head and neck squamous cell carcinoma. What is the place of bronchoscopy and upper GI endoscopy?
To determine the place of bronchoscopy and upper GI endoscopy in the initial staging of head and neck squamous cell carcinoma (HNSCC). A 10-year retrospective study was conducted on a series of 838
[Squamous intraepithelial neoplasia (WHO 2005). Precancerous lesions of the head and neck region].
The recent WHO classification 2005 applies the concept of intraepithelial neoplasia to the head and neck region and classification SIN 3 is equivalent to former carcinoma in situ.
Endoskopie in der HNO


Trägt Nikotin zur Krebsentstehung im oberen Aerodigestivtrakt bei?
Nicotine induces genotoxic effects in human target cells of carcinogenesis in the upper aerodigestive tract at relevant concentrations, suggesting that nicotine may contribute directly to tumor initiation resulting from smoking.
Aktuelle Epidemiologie des Ösophaguskarzinoms und des Kardiakarzinoms in Deutschland
In Germany, during the past 15-20 years, the incidence of esophageal AC and presumably also of AC of the cardia has increased, while that of squamous cell carcinoma of the esophagus has remained largely constant.
Photodynamic therapy of early squamous cell carcinomas of the esophagus: a review of 31 cases.
Photodynamic therapy eradicates early squamous cell carcinomas of the esophagus efficiently and was more phototoxic, induced a shorter period of photosensitization of the skin, and had better selectivity than either of the other photosensitizers.
Systematic esophageal endoscopy screening in patients previously treated for head and neck squamous-cell carcinoma.
It is found that patients with initial oropharyngeal tumors had a significantly higher risk of metachronous esophageal SCC, compared to the other tumor sites (P < 0.02 with Fisher exact test).
Oesophageal squamous cell neoplasia in head and neck cancer patients: upregulation of COX-2 during carcinogenesis
It is suggested that COX-2 upregulation contributes to oesophageal squamous carcinogenesis in HNC patients and future studies are needed to evaluate the chemopreventive potential of COx-2 inhibitors in this high-risk group.
Screening for oesophageal neoplasia in patients with head and neck cancer
The risk of squamous cell neoplasia of the oesophagus is high in patients with (previous) head and neck cancer and surveillance is recommended in this high-risk group.