“Topological Significance” Analysis of Gene Expression and Proteomic Profiles from Prostate Cancer Cells Reveals Key Mechanisms of Androgen Response

@inproceedings{Vellaichamy2010TopologicalSA,
  title={“Topological Significance” Analysis of Gene Expression and Proteomic Profiles from Prostate Cancer Cells Reveals Key Mechanisms of Androgen Response},
  author={Adaikkalam Vellaichamy and Zolt{\'a}n Dezso and Lellean JeBailey and Arul M. Chinnaiyan and Arun Sreekumar and Alexey I. Nesvizhskii and Gilbert S. Omenn and Andrej Bugrim},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND The problem of prostate cancer progression to androgen independence has been extensively studied. Several studies systematically analyzed gene expression profiles in the context of biological networks and pathways, uncovering novel aspects of prostate cancer. Despite significant research efforts, the mechanisms underlying tumor progression are poorly understood. We applied a novel approach to reconstruct system-wide molecular events following stimulation of LNCaP prostate cancer… CONTINUE READING
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