“Thinking without thinking” about natalizumab and PML

@article{Ransohoff2007ThinkingWT,
  title={“Thinking without thinking” about natalizumab and PML},
  author={Richard M. Ransohoff},
  journal={Journal of the Neurological Sciences},
  year={2007},
  volume={259},
  pages={50-52}
}
  • R. Ransohoff
  • Published 15 August 2007
  • Medicine
  • Journal of the Neurological Sciences
The novel multiple sclerosis (MS) therapeutic natalizumab has taken neurologists and their MS patients on a roller-coaster ride: initial encouraging efficacy data led to expedited release in the United States, followed by suspension of dosing with the unexpected occurrence of progressive multifocal leukoencephalopathy (PML) in three clinical trial participants. The drug was re-released in 2006, in a restricted distribution format. Aside from PML, natalizumab treatment was not associated with… 
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