“Run-down” of the Ca current during long whole-cell recordings in guinea pig heart cells: role of phosphorylation and intracellular calcium

@article{Belles1988RundownOT,
  title={“Run-down” of the Ca current during long whole-cell recordings in guinea pig heart cells: role of phosphorylation and intracellular calcium},
  author={B. Belles and Claire O. Mal{\'e}cot and J{\"u}rgen Hescheler and W. Trautwein},
  journal={Pfl{\"u}gers Archiv},
  year={1988},
  volume={411},
  pages={353-360}
}
We examined by a statistical approach the decrease of the Ca current (“run-down”) during long-lasting recordings with the whole-cell patch-clamp technique in guinea pig ventricular myocytes. The results are as follows. (1) Run-down of the Ca current (I Ca) occurs in three phases (T1–T3). T1 (38±19 min,n=135) and T3 (35±17 min,n=23) are characterized by a slow rate of decay ofI Ca [90±20 and 60±20 nA·cm−2·min−1, respectively]. T1 and T3 are separated by T2 (6±4 min,n=135) during which the… CONTINUE READING
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Effects of protein phosphatases on the open probabilities of the isoproterenol-sensitive plasma membrane calcium channels in heart muscle

  • J Hescheler, M Kameyama, W Trautwein, G Mieskes, H-D Soeling
  • Adv Prot Phosphatases
  • 1986
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