“Non-hypercalcemic” analogs of 1α,25 dihydroxy vitamin D augment the induction of creatine kinase B by estrogen and selective estrogen receptor modulators (SERMS) in osteoblast-like cells and rat skeletal organs

@article{Somjen2000NonhypercalcemicAO,
  title={“Non-hypercalcemic” analogs of 1$\alpha$,25 dihydroxy vitamin D augment the induction of creatine kinase B by estrogen and selective estrogen receptor modulators (SERMS) in osteoblast-like cells and rat skeletal organs},
  author={D. Somjen and A. Waisman and Y. Weisman and A. Kaye},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2000},
  volume={72},
  pages={79-88}
}
We have demonstrated previously that daily treatments for 3 days with the so-called "non-hypercalcemic" analogs of 1alpha,25 dihydroxy vitamin D in ROS 17/2.8 osteoblast-like cells, stimulate the specific activity of creatine kinase BB (CK), and that such treatment with these analogs followed by a single treatment with gonadal steroids, upregulates responsiveness and sensitivity to estradiol 17beta (E(2)) for the induction of CK. This study was designed to determine if these same "non… Expand
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