“Nihilism” of chronic heart failure therapy in children and why effective therapy is withheld

  title={“Nihilism” of chronic heart failure therapy in children and why effective therapy is withheld},
  author={D. Schranz and N. Voelkel},
  journal={European Journal of Pediatrics},
  pages={445 - 455}
  • D. Schranz, N. Voelkel
  • Published 2016
  • Medicine
  • European Journal of Pediatrics
  • AbstractMajor advances in chronic heart failure (cHF) therapy have been achieved and documented in adult patients, while research regarding the mechanisms and therapy of cHF in children has lagged behind. Based on receptor physiological studies and pharmacological knowledge, treatment with specific ß1-adrenergic receptor blocker (ARB), tissue angiotensin-converting enzyme inhibitor (ACE-I), and mineralocorticoid antagonists have to be recommended in children despite lack of sufficient data… CONTINUE READING
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