“Nihilism” of chronic heart failure therapy in children and why effective therapy is withheld

@article{Schranz2016NihilismOC,
  title={“Nihilism” of chronic heart failure therapy in children and why effective therapy is withheld},
  author={Dietmar Schranz and Norbert Felix Voelkel},
  journal={European Journal of Pediatrics},
  year={2016},
  volume={175},
  pages={445-455}
}
AbstractMajor advances in chronic heart failure (cHF) therapy have been achieved and documented in adult patients, while research regarding the mechanisms and therapy of cHF in children has lagged behind. Based on receptor physiological studies and pharmacological knowledge, treatment with specific ß1-adrenergic receptor blocker (ARB), tissue angiotensin-converting enzyme inhibitor (ACE-I), and mineralocorticoid antagonists have to be recommended in children despite lack of sufficient data… CONTINUE READING

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