“Lymphokines”: Non-Antibody Mediators of Cellular Immunity generated by Lymphocyte Activation

@article{Dumonde1969LymphokinesNM,
  title={“Lymphokines”: Non-Antibody Mediators of Cellular Immunity generated by Lymphocyte Activation},
  author={Dudley Cohen Dumonde and R. A. Wolstencroft and G. S. Panayi and Margaret Matthew and J. Morley and W. T. Howson},
  journal={Nature},
  year={1969},
  volume={224},
  pages={38-42}
}
Four principal features of cellular immunity in the guinea-pig are mediated by a group of soluble factors generated by antigen-activated lymphocytes. These “lymphokines” are different from classical antibodies. 
In vitro Studies on Human Lymphocyte Factors of Sensitized Lymphocytes
It has been shown that sensitized lymphocytes after exposure to antigen generate certain soluble factors which seem to be humoral mediators of cellular immunity.
Biological Properties of Lymphokines
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The immune response induced by a foreign agent (antigen) which has penetrated the natural defense barriers and gained access to the host appears to take two basic forms, which often function in concert and help to facilitate destruction and removal of the antigen.
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Macrophages as Effectors of Cell-Mediated Immunity and their role in Immunity are studied in detail in this chapter.
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Lymphoid tissues are the home of the immune system and essential for protection against bacterial and viral invasion and against significant cellular changes.
Antigen-induced non-specific suppressor factor in sheep efferent lymph is prostaglandin E2.
Efferent lymph from the popliteal node of sheep challenged with antigen was found to suppress the in vitro transformation of sheep peripheral blood lymphocytes to a variety of antigens. The
Cell Surveillance Model for Lymphocyte Cooperation
A model is proposed for clonal proliferation and antibody production of B lymphocytes. It suggests that changes in the B cell surface due to specific antigen binding are detected by T lymphocytes,
Inflammatory factors produced by sensitized guinea-pig peripheral blood lymphocytes
The supernatants obtained from stimulated tuberculin-sensitive guinea-pig peripheral blood lymphocytes contain factors that induce a cutaneous inflammatory response in normal guinea-pigs similar to
A mouse system for demonstrating the presence of inflammatory factors from human peripheral blood lymphocytes
An assay system is described that allows the presence of inflammatory factors in supernatants from stimulated tuberculin-sensitive human peripheral blood lymphocytes to be demonstrated, by the
Studies on in vitro models of cellular immunity: the role of T and B cells in the secretion of lymphotoxin.
TLDR
Spleens from congenitally athymic Nu/Nu mice failed to produce LT when stimulated with pokeweed mitogen or phytohemagglutinin and theta-positive cells were responsible for LT production in spleens removed from X-irradiated and bone marrow- or thymus-reconstituted animals.
Lymphocyte Mitogenic Factor in Man
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A soluble mediator is involved in the transformation of human lymphocytes by specific antigen and may play a role in the development of anticancer drugs.
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    Proceedings of the National Academy of Sciences of the United States of America
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