“Homology” in proteins and nucleic acids: A terminology muddle and a way out of it

@article{Reeck1987HomologyIP,
  title={“Homology” in proteins and nucleic acids: A terminology muddle and a way out of it},
  author={Gerald R. Reeck and Christoph de Ha{\"e}n and David C. Teller and Russell F. Doolittle and Walter M. Fitch and Richard E. Dickerson and Pierre Chambon and A. D. McLachlan and Emanuel Margoliash and Thomas Hughes Jukes and Emile Zuckerkandl},
  journal={Cell},
  year={1987},
  volume={50}
}
“Homology” has the precise meaning in biology of “having a common evolutionary origin,” but it also carries the loose meaning of “possessing similarity or being matched.” Its rampant use in the loose sense is clogging the literature on protein and nucleic acid sequence comparisons with muddy writing and, in some cases, muddy thinking In its precise biological meaning, “homology” is a concept of quality. The word asserts a type of relationship between two or more things. Thus, amino acid or… Expand

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