“Deficiency” of Mitochondria in Muscle Does Not Cause Insulin Resistance


Based on evidence that patients with type 2 diabetes (T2DM), obese insulin-resistant individuals, and lean insulin-resistant offspring of parents with T2DM have ~30% less mitochondria in their muscles than lean control subjects, it appears to be widely accepted that mitochondrial "deficiency" is responsible for insulin resistance. The proposed mechanism for… (More)
DOI: 10.2337/db12-1107


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