“But Mouse, You Are Not Alone”: On Some Severe Acute Respiratory Syndrome Coronavirus 2 Variants Infecting Mice

@article{Kuiper2021ButMY,
  title={“But Mouse, You Are Not Alone”: On Some Severe Acute Respiratory Syndrome Coronavirus 2 Variants Infecting Mice},
  author={Michael J. Kuiper and Laurence O. W. Wilson and Shruthi Mangalaganesh and Carol Lee and Daniel Reti and Seshadri S. Vasan},
  journal={ILAR Journal},
  year={2021},
  volume={62},
  pages={48 - 59}
}
In silico predictions combined with in vitro, in vivo and in situ observations collectively suggest that mouse adaptation of the SARS-CoV-2 virus requires an aromatic substitution in position 501 or position 498 (but not both) of the spike protein’s receptor binding domain. This effect could be enhanced by mutations in positions 417, 484, and 493 (especially K417N, E484K, Q493K and Q493R), and to a lesser extent by mutations in positions 486 and 499 (such as F486L and P499T). Such enhancements… 

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