“A surviving myth” – corticosteroids are still considered ulcerogenic by a majority of physicians

  title={“A surviving myth” – corticosteroids are still considered ulcerogenic by a majority of physicians},
  author={Jan Mart{\'i}nek and Kristyna Hlavova and Filip Z{\'a}vada and Bohumil Seifert and Stanislav Rejchrt and Ondřej Urban and Miroslav Zavoral},
  journal={Scandinavian Journal of Gastroenterology},
  pages={1156 - 1161}
Abstract Objective. Evidence does not support an association between systemic corticosteroid use and the development of peptic ulcer disease (PUD) and prophylactic anti-ulcer therapy is not routinely indicated. The aim was to find out the opinion of physicians in the Czech Republic on corticosteroid-induced ulcers. Materials and methods. A questionnaire-based study targeting 360 physicians of different specialties (100 from Gastroenterology, 100 from General Practice, 80 from Pneumology… 

Peptic ulcer disease in endogenous hypercortisolism: myth or reality?

It is possible that neither exogenous nor endogenous corticosteroid excess directly causes peptic ulcer or Helicobacter pylori infection, and the use of proton pump inhibitors is not compulsory for hypercortisolism of any type.

Do glucocorticoids affect the development of ulcers and erosions of the upper gastrointestinal tract in patients taking NSAIDs.

The use of GC does not increase the risk of erosion and ulcers of the upper GI tract when taking NSAIDs, according to a retrospective comparison of gastrointestinal lesions detected in patients with RD during endoscopic examination.

Steroid ulcers: Any news?

  • M. Guslandi
  • Medicine, Biology
    World journal of gastrointestinal pharmacology and therapeutics
  • 2013
Despite the survival of the steroid ulcer myth in the medical culture, pharmacological protection against steroid-induced peptic ulcers is a rare necessity while the best prophylactic strategy still remains to be determined.

Risk factors for upper gastrointestinal bleeding requiring hospitalization

Varices was the most common cause of UGIB, followed closely by ulcers, and the proportion of patients who had cancer was higher in the elderly group than in the middle-aged group, while 7% of patientsWho had UG IB took NSAIDs, clopidogrel, or Chinese herbal medicines.

Non-Helicobacter pylori, non-NSAID peptic ulcer disease: an important consideration in the evaluation of patients with gastric or duodenal ulcers.

The various less prevalent causes of peptic ulceration in non-H.

Safety of perioperative dexamethasone administration in children: time for reflection?

  • K. YeeR. Cox
  • Medicine
    Canadian Journal of Anesthesia/Journal canadien d'anesthésie
  • 2013
The purpose of this editorial is to review the current evidence for the safety profile of dexamethasone, a synthetic corticosteroid, given that the drug is now widely used in the perioperative period in both children and adults.

This month in Scandinavian Journal of Gastroenterology

This issue of Scandinavian Journal of Gastroenterology depicts the broad spectrum of gastroenterology and discusses the pathophysiological mechanisms underlying mucosal ulcerations in inflammatory bowel disease.

Who Needs Gastroprotection in 2020?

H. pylori test and treat should be offered to older patients starting NSAIDS, while PPIs should be prescribed to patients that are at high risk of developing PUD and at risk of dying from PUD complications.

Corticosteroids and risk of gastrointestinal bleeding: a systematic review and meta-analysis

Criminal history of corticosteroid use, use of non-steroidal anti-inflammatory drugs (NSAIDs) or gastroprotective drugs, and history of peptic ulcer were excluded.



Corticosteroid use and peptic ulcer disease: role of nonsteroidal anti-inflammatory drugs.

The high risk for peptic ulcer disease associated with combined use of NSAIDs and corticosteroids indicates the need to prescribe this drug combination cautiously.

Association of adrenocorticosteroid therapy and peptic-ulcer disease.

It is strongly suggested that corticosteroids do increase the risk of peptic ulcers and gastrointestinal hemorrhage.

Gastroprotection in neurosurgery: the practice in Great Britain.

The findings indicate an increase in the administration of gastroprotective agents within neurosurgery, however, the use of H2 antagonists in the intensive care unit and theUse of gastroProtective agents with corticosteroids may not be warranted.

Nonassociation of adrenocorticosteroid therapy and peptic ulcer.

Although there are many anecdotal reports of the development of peptic ulcer in patients receiving adrenocorticosteroid (steroid) treatment that go back to the early days of cortisone therapy, no definitive description can be found, and no objective confirmation of this association exists.

Consequences of high-dose steroid therapy for acute spinal cord injury.

Although the NASCIS-2 protocol may promote early infectious complications, it has no adverse impact on long-term outcome in patients with ASCIs.

Corticosteroid therapy for patients with acute exacerbations of chronic obstructive pulmonary disease: a systematic review.

Short courses of systemic corticosteroids in acute exacerbations of COPD have been shown to improve spirometric outcomes and clinical outcomes and good-quality evidence is shown.

Corticosteroids and peptic ulcer: meta‐analysis of adverse events during steroid therapy

A meta‐analysis was performed to determine whether corticosteroid therapy induces the development of peptic ulcer and other putative complications of steroid therapy.

Gastroprotective role of glucocorticoid hormones.

The findings overviewed here support the idea that glucocorticoid hormones released in response to acute stress or NSAIDs act as gastroprotective substances and exert many of the same actions in the stomach as prostaglandins and nitric oxide as well as capsaicin-sensitive afferent neurons.