’Postconditioning’ the human heart: Multiple balloon inflations during primary angioplasty may confer cardioprotection

  title={’Postconditioning’ the human heart: Multiple balloon inflations during primary angioplasty may confer cardioprotection},
  author={Chad E. Darling and Paolo Solari and Clare S. Smith and Mark I. Furman and Karin Przyklenk},
  journal={Basic Research in Cardiology},
Growing evidence from experimental models suggests that relief of myocardial ischemia in a stuttering manner (i.e., ’postconditioning’ [PostC] with brief cycles of reperfusion-reocclusion) limits infarct size. However, the potential clinical efficacy of PostC has, to date,been largely unexplored. Using a retrospective study design, our aim was to test the hypothesis that creatine kinase release (CK: clinical surrogate of infarct size) would be attenuated in ST-segment elevation myocardial… CONTINUE READING

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‘ Elderly ’ mice are refractory to postconditioning - induced cardioprotection

C Darling, M Maynard, P Whittaker, K Przyklenk
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Post - conditioning inhibits mitochondrial permeability transition

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