‘Unconventional’ Coordination Chemistry by Metal Chelating Fragments in a Metalloprotein Active Site

Abstract

The binding of three closely related chelators: 5-hydroxy-2-methyl-4H-pyran-4-thione (allothiomaltol, ATM), 3-hydroxy-2-methyl-4H-pyran-4-thione (thiomaltol, TM), and 3-hydroxy-4H-pyran-4-thione (thiopyromeconic acid, TPMA) to the active site of human carbonic anhydrase II (hCAII) has been investigated. Two of these ligands display a monodentate mode of… (More)
DOI: 10.1021/ja500616m

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Cite this paper

@inproceedings{Martin2014UnconventionalCC, title={‘Unconventional’ Coordination Chemistry by Metal Chelating Fragments in a Metalloprotein Active Site}, author={David P. Martin and Patrick G. Blachly and Amy R. Marts and Tessa M. Woodruff and C{\'e}sar Augusto Fernandes de Oliveira and J. Andrew McCammon and David L Tierney and Seth M Cohen}, booktitle={Journal of the American Chemical Society}, year={2014} }