‘Umpolung’ Reactivity in Semiaqueous Amide and Peptide Synthesis

@article{Shen2010UmpolungRI,
  title={‘Umpolung’ Reactivity in Semiaqueous Amide and Peptide Synthesis},
  author={Bo Shen and Dawn M. Makley and J. N. Johnston},
  journal={Nature},
  year={2010},
  volume={465},
  pages={1027 - 1032}
}
The amide bond is one of nature’s most common functional and structural elements, as the backbones of all natural peptides and proteins are composed of amide bonds. Amides are also present in many therapeutic small molecules. The construction of amide bonds using available methods relies principally on dehydrative approaches, although oxidative and radical-based methods are representative alternatives. In nearly every example, carbon and nitrogen bear electrophilic and nucleophilic character… Expand
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