‘The obesity paradox’: a reconsideration of obesity and the risk of preterm birth

  title={‘The obesity paradox’: a reconsideration of obesity and the risk of preterm birth},
  author={Abraham Tsur and Jonathan A. Mayo and Ronald J. Wong and Gary M. Shaw and David K. Stevenson and Jeffrey B. Gould},
  journal={Journal of Perinatology},
Objective:The association between obesity and spontaneous preterm births (sPTBs) has been shown to be influenced by obesity-attendant comorbidities. Our objective was to better understand the complex relationship of obesity and its attendant comorbidities with sPTBs.Study Design:A retrospective analysis utilizing maternally linked hospital and birth certificate records of 2 049 196 singleton California deliveries from 2007 to 2011. Adjusted relative risks (aRRs) for sPTBs were estimated using… 

Adverse perinatal outcomes for obese women are influenced by the presence of comorbid diabetes and hypertensive disorders

It is suggested that comorbidities such as diabetes and hypertensive disorders should be considered when relating maternal obesity to adverse perinatal outcomes.

Neonatal Morbidity in the Offspring of Obese Women Without Hypertension or Diabetes.

In patients who labor, maternal obesity is an independent risk factor for significant neonatal morbidity, even in the absence of hypertensive disorders or diabetes.

Cervicovaginal Inflammatory Cytokines, Obesity and Inter-Pregnancy Interval Negatively Affect Pregnancy Duration in Pregnant Women at High-Risk for Recurrent Spontaneous Preterm Birth

High BMI, short IPI and high CVF inflammatory cytokines’ levels negatively affect pregnancy duration especially in women with history of recurrent PTB, and early prophylactic CC for women at high-risk of SPTB can modulate local immune disturbance, reduce incidence of SP TB and prolong pregnancy duration.

Explaining the Black-White Disparity in Preterm Birth: A Consensus Statement From a Multi-Disciplinary Scientific Work Group Convened by the March of Dimes

In 2017–2019, the March of Dimes convened a workgroup with biomedical, clinical, and epidemiologic expertise to review knowledge of the causes of the persistent Black-White disparity in preterm birth

Risk of early birth by body mass index in a propensity score‐matched sample: A retrospective cohort study

Evaluate the risk of preterm (<37 weeks) or early term birth (37 or 38 weeks) by body mass index (BMI) in a propensity score‐matched sample.

Influence of Tocolytic Therapy with Hexoprenaline on Heart Rate Variability, Lipid Spectrum and Glycemic Level in Obese Pregnant Women

The effect of hexoprenaline tocolysis on heart rate variability, lipid spectrum and glycaemia level in obese pregnant women remain unexplored.



Maternal obesity and pregnancy outcome: a study of 287 213 pregnancies in London

Maternal obesity carries significant risks for the mother and foetus and the risk increases with the degree of obesity and persists after accounting for other confounding demographic factors.

Obstetric and Neonatal Risks Among Obese Women Without Chronic Disease

Preregnancy obesity is associated with increased risks of a wide range of adverse pregnancy and neonatal outcomes among women without chronic diseases.

Prepregnancy Obesity and Risks of Stillbirth

Increased risks were observed across all gestational ages, and some evidence of heterogeneity of the associations was observed by race-ethnicity and parity.

Obesity, gestational weight gain and preterm birth: a study within the Danish National Birth Cohort.

The aim of the present study was to assess the impact of obesity and gestational weight gain on the risk of subtypes of preterm birth, because little is known about these associations. The study

Association among Maternal Obesity, Cervical Length, and Preterm Birth

Women with a higher BMI group had longer mid‐trimester cervical length, and correspondingly reduced SPTB, however, the decreased risk of SPTB was not associated with cervical length.

Prepregnancy weight and the risk of adverse pregnancy outcomes.

Higher maternal weight before pregnancy increases the risk of late fetal death, although it protects against the delivery of a small-for-gestational-age infant.

Inflammatory biomarkers and spontaneous preterm birth among obese women

  • M. WallensteinL. Jelliffe‐Pawlowski G. Shaw
  • Medicine, Biology
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2016
Three serum biomarkers indicative of inflammation to be associated with spontaneous preterm birth among obese women are identified: sVEGFR3, sIL-2RA and sTNFR1.

Maternal obesity and risk of preterm delivery.

In Sweden, maternal overweight and obesity during pregnancy were associated with increased risks of preterm delivery, especially extremely preterm Delivery, and these associations should be assessed in other populations.