‘Sweet Dreams’, ‘Happy Days’ and elevated 24-h urine 5-hydroxyindoleacetic acid excretion

@article{Hallin2013SweetD,
  title={‘Sweet Dreams’, ‘Happy Days’ and elevated 24-h urine 5-hydroxyindoleacetic acid excretion},
  author={Magnus Hallin and Kamal Mofida Mahmoud and Ananth K Viswanath and Rousseau Gama},
  journal={Annals of Clinical Biochemistry},
  year={2013},
  volume={50},
  pages={80 - 82}
}
We report two patients with markedly elevated 24-h urine 5-hydroxyindoleacetic acid (5-HIAA) excretion due to over-the-counter (OTC) self-medication with 5-hydroxytryptophan (5-HTP). It is important to recognize that OTC medication may cause increased ‘false-positive‘ 5-HIAA excretion to prevent undue patient anxiety and unnecessary further investigation for carcinoid disease. Discordance between chromogranin A and 24-h urine 5-HIAA results should alert to the possibility of false-positive or… Expand
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