‘Sweet Dreams’, ‘Happy Days’ and elevated 24-h urine 5-hydroxyindoleacetic acid excretion

  title={‘Sweet Dreams’, ‘Happy Days’ and elevated 24-h urine 5-hydroxyindoleacetic acid excretion},
  author={Magnus Hallin and Kamal Mofida Mahmoud and Ananth K Viswanath and Rousseau Gama},
  journal={Annals of Clinical Biochemistry},
  pages={80 - 82}
We report two patients with markedly elevated 24-h urine 5-hydroxyindoleacetic acid (5-HIAA) excretion due to over-the-counter (OTC) self-medication with 5-hydroxytryptophan (5-HTP). It is important to recognize that OTC medication may cause increased ‘false-positive‘ 5-HIAA excretion to prevent undue patient anxiety and unnecessary further investigation for carcinoid disease. Discordance between chromogranin A and 24-h urine 5-HIAA results should alert to the possibility of false-positive or… Expand
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Increase of urinary 5-hydroxyindoleacetic acid excretion but not serum chromogranin A following over-the-counter 5-hydroxytryptophan intake.
Oral 5-HTP increases urinary 5-HIAA excretion with considerable interindividual variation and should be added to popular references as a substance that may cause increased 5- HIAAexcretion. Expand
The incidence of elevations in urine 5-hydroxyindoleacetic acid.
Given the frequency of elevated results, HIAA should be used to support the diagnoses of carcinoid only when consistent with other objective findings. Expand
The clinical and laboratory correlates of an increased urinary 5-hydroxyindoleacetic acid.
While the specificity was 88%, 5-HIAA is relatively insensitive in the diagnosis of carcinoid tumours and a more widespread use of diagnostic imaging including isotope scanning with labelled metaiodo-benzylguanidine, vasoactive intestinal peptide and octreotide is suggested. Expand
The dietary supplement 5-hydroxytryptophan and urinary 5-hydroxyindole acetic acid
A 56-year-old woman presented with diarrhea (6–8 loose stools daily with no obvious blood) that had persisted for 12 weeks and the patient reported having some fecal incontinence. Expand
5-Hydroxytryptophan: a clinically-effective serotonin precursor.
  • T. Birdsall
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Therapeutic administration of 5-HTP has been shown to be effective in treating a wide variety of conditions, including depression, fibromyalgia, binge eating associated with obesity, chronic headaches, and insomnia. Expand
Serotonin content of foods: effect on urinary excretion of 5-hydroxyindoleacetic acid.
Using a highly specific radioenzymatic assay, the serotonin concentration in 80 types of foods was determined andgestion of these fruits and nuts resulted in an increase in urinary 5-hydroxyindoleacetic acid excretion with no change in platelet serotonin concentration. Expand
Tryptophan and 5-hydroxytryptophan for depression.
The available evidence suggests these substances were better than placebo at alleviating depression, but further studies are needed to evaluate the efficacy and safety of 5-HTP and tryptophan before their widespread use can be recommended. Expand
Role of neuropeptides and serotonin in the diagnosis of carcinoid tumors.
Although measurements of plasma neuropeptide levels may be helpful in occasional patients with carcinoid tumors, it is concluded that measurements of serotonin overproduction--such as 5-hydroxyindoleacetic acid excretion--are of more general value. Expand
Chromogranin A, neuron specific enolase, carcinoembryonic antigen, and hydroxyindole acetic acid evaluation in patients with neuroendocrine tumors
The role of biomarkers currently used in the diagnosis, prognosis, and follow-up of patients with neuroendocrine tumors (NETs) is examined. Expand
Chromogranin A: is it a useful marker of neuroendocrine tumors?
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