‘Subclinical MS’: follow‐up of four cases

@article{Hakiki2008SubclinicalMF,
  title={‘Subclinical MS’: follow‐up of four cases},
  author={Bahia Hakiki and Benedetta Goretti and Emilio Portaccio and Valentina Zipoli and Maria Pia Amato},
  journal={European Journal of Neurology},
  year={2008},
  volume={15}
}
Background and purpose:  Subclinical multiple sclerosis (S‐MS) can be defined as the discovery of characteristic lesions at magnetic resonance (MR) or at autopsy, in the absence of clinical evidence consistent with MS. To describe four cases of S‐MS cases followed‐up with clinical and MR examinations. 
View on Wiley
ncbi.nlm.nih.gov
40 Citations
Highly Influential Citations
1
Background Citations
7
Results Citations
1

40 Citations

[Radiologically isolated syndrome as a possible preclinical stage of primary-progressive multiple sclerosis].
TLDR
A clinical case-report of transformation of radiologically isolated syndrome to primary-progressive multiple sclerosis is presented and a review of international and Russian data on the comparison of clinical and MRI characteristics of PPMS is provided.
[Radiologically isolated syndrome - MRI criteria and management tactic].
TLDR
Brain MRI findings in patients with asymptomatic lesions in the white matter can be interpreted as demyelinating lesions in some cases, but in the absence of clinical symptoms characteristic of multiple sclerosis, a diagnosis of MS cannot be made in the patients with these incidental findings.
Anomalies Characteristic of Central Nervous System Demyelination: Radiologically Isolated Syndrome.
Recent Developments in the Early Diagnosis and Management of Multiple Sclerosis
  • A. P. Ross, Ben W Thrower
  • Medicine, Psychology
    The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses
  • 2010
TLDR
This article addresses the need for new and updated information on current diagnostic methods for MS, optimal time to initiate treatment of MS, and emerging therapies for MS.
The radiologically isolated syndrome: take action when the unexpected is uncovered?
TLDR
The incidental detection of multiple sclerosis (MS) typical central nervous system (CNS) lesions fulfilling MRI criteria for dissemination in space (radiologically isolated syndrome, RIS) and its diagnostic, prognostic and therapeutic implications are discussed.
Radiologically isolated syndrome: an uncommon finding at a university clinic in a high-prevalence region for multiple sclerosis
TLDR
RIS, according to present criteria, is an uncommon finding in a tertiary hospital setting in a high-prevalence region for MS where awareness and clinical suspicion of MS is common.
Multiple sclerosis risk in radiologically uncovered asymptomatic possible inflammatory-demyelinating disease
TLDR
Patients with RAPIDD develop MS at a similar rate to treated patients (and less frequently than placebo groups) with clinically isolated syndromes from prior randomized controlled studies.
The radiologically isolated syndrome.
  • C. Lebrun
  • Medicine, Psychology
    Revue neurologique
  • 2015
How much radiologically isolated syndrome suggestive of multiple sclerosis is multiple sclerosis?
TLDR
In the published cohorts, during the follow-up period, many patients not only developed an increased number of T2-lesions on MRI, an evidence of temporospatial dissemination – and therefore MS by MRI criteria, but they also exhibited clinical manifestations of central nervous system dysfunction, which is highly suggestive of demyelinating disease.
[Radiologically isolated syndrome: multiple sclerosis based solely on MRI findings?].
TLDR
The radiologically isolated syndrome has to be classified as a possible preliminary phase of the clinical manifestation of MS in a subgroup of patients and entails in-depth therapeutic considerations.
...
...

References

SHOWING 1-10 OF 15 REFERENCES
A clinical patho‐anatomical study of clinically silent multiple sclerosis
  • T. Engell
  • Medicine, Psychology
    Acta neurologica Scandinavica
  • 1989
TLDR
In the silent group, the MS plaques were located mainly in the periventricular areas, and this may explain the silent nature of the disease.
Imaging brain damage in first‐degree relatives of sporadic and familial multiple sclerosis
TLDR
The objective was to assess brain damage in first‐degree relatives of patients with sporadic and familial multiple sclerosis (MS) and to investigate the role of EMT in brain damage.
Unexpected multiple sclerosis: follow-up of 30 patients with magnetic resonance imaging and clinical conversion profile
TLDR
A descriptive retrospective study of clinical and 5 year MRI follow-up in patients with subclinical demyelinating lesions fulfilling MRI Barkhof–Tintoré criteria with a normal neurological examination, which is the first cohort of CIS with preclinical follow- up.
MRI markers of destructive pathology in multiple sclerosis-related cognitive dysfunction
Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”
TLDR
New evidence and consensus now strengthen the role of these criteria in the multiple sclerosis diagnostic workup to demonstrate dissemination of lesions in time, to clarify the use of spinal cord lesions, and to simplify diagnosis of primary progressive disease.
Cognitive impairment in probable multiple sclerosis
  • A. Achiron, Y. Barak
  • Medicine, Psychology
    Journal of neurology, neurosurgery, and psychiatry
  • 2003
TLDR
Prevalent cognitive impairment already exists at onset of multiple sclerosis, and verbal abilities and attention span were most frequently affected.
MRI in familial multiple sclerosis
TLDR
The results of the present study indicate that subclinical MS may be present in apparently normal members of multiplex families.
Cognitive dysfunction in patients with clinically isolated syndromes or newly diagnosed multiple sclerosis
TLDR
It is suggested that cognitive impairment may predate the appearance of gross structural abnormalities on MRI and serve as an early marker of disease activity in MS.
Cognitive dysfunction in early-onset multiple sclerosis: a reappraisal after 10 years.
TLDR
In a cohort of patients with early-onset multiple sclerosis, the long-term evolution of cognitive deficits, their relationship to the disease's clinical progression, and their effects on daily life are reassessed.
Italian Multicentre Study on Dementia (SMID): a neuropsychological test battery for assessing Alzheimer's disease.
...
...