‘Smoke in the air’: a rare cerebrovascular cause of neurological signs and symptoms in a young adult

@article{Ismail2015SmokeIT,
  title={‘Smoke in the air’: a rare cerebrovascular cause of neurological signs and symptoms in a young adult},
  author={Imtiaz Ismail and Khalid Al-Khafaji and Monica Mutyala and Saurabh Aggarwal and Nawfal Al-khafaji and Daniela Kovacs and Sandeep Khosla and Rohit Arora},
  journal={Journal of Community Hospital Internal Medicine Perspectives},
  year={2015},
  volume={5}
}
Moyamoya disease is a rare neurological condition that affects children and adults of all ages. It is characterized by chronic, progressive stenosis of the circle of Willis that ultimately leads to the development of extensive collateral vessels. Presenting symptoms are usually due to cerebral ischemia or hemorrhage. The Japanese term moyamoya (meaning puffy or obscure) was coined to describe the characteristic ‘smoke in the air’ appearance of these vessels on cerebral angiography. Moyamoya has… 
2 Citations
Panobinostat, a histone deacetylase inhibitor, rescues the angiogenic potential of endothelial colony-forming cells in moyamoya disease
TLDR
It is demonstrated that panobinostat increases the angiogenic ability of MMD ECFCs by regulating RALDH2 acetylation and might be a potent therapeutic option for MMD patients.
Editor's notes
  • R. Ferguson
  • Medicine
    Journal of community hospital internal medicine perspectives
  • 2015
TLDR
This issue, volume 5, #4, there are 14 manuscripts, a promising new pharmacologic approach to preventing delirium in the ICU in geriatric patients, and the need for peer reviewers is greater than ever; so, the readership is invited to participate in the peer review.

References

SHOWING 1-10 OF 19 REFERENCES
Moyamoya disease in adults: the role of cerebral revascularization.
TLDR
The purpose of this article is to review the pertinent general features of moyamoya disease, examine the clinical characteristics associated with the adult-onset form of this disease, and provide a detailed discussion regarding the indications, operative techniques, and outcomes of direct and indirect revascularization surgical procedures.
Moyamoya disease: current concepts and future perspectives
Cerebrovascular "moyamoya" disease. Disease showing abnormal net-like vessels in base of brain.
TLDR
The disease which produces an abnormal net-like blood vessel picture in the base of the brain might have been observed in this country during these 10 years, but visualization of such an angiogram seems not to have been noticed as indicating a disease with characteristic features.
Moyamoya disease: a review.
TLDR
In this review, some of the recent advances in the study of the genetics and pathogenesis of the disease are reviewed and the clinical manifestation and the role of surgery are discussed.
Cerebrovascular Moyamoya disease.
TLDR
The clinical features of tetany, convulsions, laryngeal spasm, Parkinsonian tremor, mental changes, irritability, and cataracts all suggested the diagnosis of hypoparathyroidism and it was suggested that routine estimation of the serum calcium on all patients with cataract would disclose a larger number of hypocalcaemic patients in the older age groups.
Spontaneous occlusion of the circle of Willis
TLDR
It is believed that this represents a new disease entity of unknown etiology with a high incidence among Japanese, and the radiological and neurological aspects of these cases have been described.
Epidemiological features of Moyamoya disease in Japan: findings from a nationwide survey
Moyamoya disease in Europe, past and present status
Review of past research and current concepts on the etiology of moyamoya disease.
TLDR
The aim of this paper is to review research on the pathogenesis of moyamoya disease to identify milestones in the direction of its true solution and to suggest the "double hit hypothesis" is probably the best explanation for the complicated pathology and epidemiology of this disease.
Diagnosis of Moyamoya Disease With Magnetic Resonance Angiography
TLDR
MRA can be an alternative to conventional angiography in typical moyamoya disease cases (the bilateral type of moyAMoya disease in children), however, in the early or the end stages of moysamoy disease, diagnosis by means of MRA should be carefully evaluated.
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