‘Smoke in the air’: a rare cerebrovascular cause of neurological signs and symptoms in a young adult

  title={‘Smoke in the air’: a rare cerebrovascular cause of neurological signs and symptoms in a young adult},
  author={Imtiaz Ismail and Khalid Al-Khafaji and Monica Mutyala and Saurabh Aggarwal and Nawfal Al-khafaji and Daniela Kovacs and Sandeep Khosla and Rohit Arora},
  journal={Journal of Community Hospital Internal Medicine Perspectives},
Moyamoya disease is a rare neurological condition that affects children and adults of all ages. It is characterized by chronic, progressive stenosis of the circle of Willis that ultimately leads to the development of extensive collateral vessels. Presenting symptoms are usually due to cerebral ischemia or hemorrhage. The Japanese term moyamoya (meaning puffy or obscure) was coined to describe the characteristic ‘smoke in the air’ appearance of these vessels on cerebral angiography. Moyamoya has… 
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Panobinostat, a histone deacetylase inhibitor, rescues the angiogenic potential of endothelial colony-forming cells in moyamoya disease
It is demonstrated that panobinostat increases the angiogenic ability of MMD ECFCs by regulating RALDH2 acetylation and might be a potent therapeutic option for MMD patients.
Editor's notes
  • R. Ferguson
  • Medicine
    Journal of community hospital internal medicine perspectives
  • 2015
This issue, volume 5, #4, there are 14 manuscripts, a promising new pharmacologic approach to preventing delirium in the ICU in geriatric patients, and the need for peer reviewers is greater than ever; so, the readership is invited to participate in the peer review.


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Moyamoya disease: current concepts and future perspectives
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In this review, some of the recent advances in the study of the genetics and pathogenesis of the disease are reviewed and the clinical manifestation and the role of surgery are discussed.
Cerebrovascular Moyamoya disease.
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It is believed that this represents a new disease entity of unknown etiology with a high incidence among Japanese, and the radiological and neurological aspects of these cases have been described.
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Diagnosis of Moyamoya Disease With Magnetic Resonance Angiography
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