‘Seed and soil’ revisited: mechanisms of site-specific metastasis

@article{Hart1982SeedAS,
  title={‘Seed and soil’ revisited: mechanisms of site-specific metastasis},
  author={Ian R. Hart},
  journal={Cancer and Metastasis Reviews},
  year={1982},
  volume={1},
  pages={5-16}
}
SummaryClinical studies have shown that malignant tumors frequently show definite metastatic patterns. This tendency for neoplasms of a particular histologic type to metastasize to a specific organ is also a characteristic of experimental animal tumor systems. Mechanical entrapment, arrest determined by specific recognition between neoplastic cells and capillaries and organ-determined modulation of tumor growth have all been suggested as mechanisms that regulate this specificity. Experimental… CONTINUE READING
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