‘Seed and soil’ revisited: mechanisms of site-specific metastasis

@article{Hart2004SeedAS,
  title={‘Seed and soil’ revisited: mechanisms of site-specific metastasis},
  author={I. Hart},
  journal={Cancer and Metastasis Reviews},
  year={2004},
  volume={1},
  pages={5-16}
}
  • I. Hart
  • Published 2004
  • Biology, Medicine
  • Cancer and Metastasis Reviews
SummaryClinical studies have shown that malignant tumors frequently show definite metastatic patterns. This tendency for neoplasms of a particular histologic type to metastasize to a specific organ is also a characteristic of experimental animal tumor systems. Mechanical entrapment, arrest determined by specific recognition between neoplastic cells and capillaries and organ-determined modulation of tumor growth have all been suggested as mechanisms that regulate this specificity. Experimental… Expand
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References

SHOWING 1-10 OF 96 REFERENCES
Do Metastases Metastasize?
Experimental Tumor Metastasis: Characteristics and Organ Specificity
Patterns of spontaneous metastasis of transplantable hepatocellular carcinomas.
  • F. Becker
  • Biology, Medicine
  • Cancer research
  • 1978
A new metastasizing mammary carcinoma model in mice: model characteristics and applications.
Organophilic tendencies of two transplantable tumors of the mouse.
Influence of lodgement site on the proliferation of metastases of Walker 256 carcinoma in the rat.
Proceedings: Tumor angiogenesis factor.
The biology of cancer invasion and metastasis.
The kinetics of the organ-specific metastasis of a transplantable reticuloendothelial tumor.
Biology of cancer invasion and metastasis.
...
1
2
3
4
5
...