‘Seed and soil’ revisited: mechanisms of site-specific metastasis

@article{Hart2004SeedAS,
  title={‘Seed and soil’ revisited: mechanisms of site-specific metastasis},
  author={Ian R. Hart},
  journal={Cancer and Metastasis Reviews},
  year={2004},
  volume={1},
  pages={5-16}
}
  • I. Hart
  • Published 2004
  • Medicine
  • Cancer and Metastasis Reviews
SummaryClinical studies have shown that malignant tumors frequently show definite metastatic patterns. This tendency for neoplasms of a particular histologic type to metastasize to a specific organ is also a characteristic of experimental animal tumor systems. Mechanical entrapment, arrest determined by specific recognition between neoplastic cells and capillaries and organ-determined modulation of tumor growth have all been suggested as mechanisms that regulate this specificity. Experimental… 
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  • 2004
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