‘Reversible chemical sphincterotomy’ by local application of glyceryl trinitrate

@article{Loder1994ReversibleCS,
  title={‘Reversible chemical sphincterotomy’ by local application of glyceryl trinitrate},
  author={P. Loder and M. Kamm and R. Nicholls and R. Phillips},
  journal={British Journal of Surgery},
  year={1994},
  volume={81}
}
Nitric oxide has emerged as one of the most important neurotransmitters mediating internal anal sphincter relaxation. The effect of glyceryl trinitrate, a nitric oxide donor, on anal tone was examined. Maximum resting pressure, predominantly a function of the smooth muscle internal anal sphincter, was measured before and 20 min after application of 0·2 per cent glyceryl trinitrate ointment in ten patients. Pressure decreased by a mean of 27 per cent (95 per cent confidence interval 18–36 per… Expand
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Paper Mentions

Interventional Clinical Trial
Autologous PRP currently has many uses in surgical and medical therapy. Compared with other regenerative therapies, PRP is easy-to-prepare, low-cost, and does not require complex… Expand
ConditionsAnal Fissure Chronic, PRP
InterventionBehavioral, Biological, Dietary Supplement, (+1 more)
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Effects of nifedipine on anorectal smooth musclein Vitro
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