‘Proteolytic switching’: opposite patterns of regulation of gelatinase B and its inhibitor TIMP-1 during human melanoma progression and consequences of gelatinase B overexpression

@inproceedings{Macdougall1999ProteolyticSO,
  title={‘Proteolytic switching’: opposite patterns of regulation of gelatinase B and its inhibitor TIMP-1 during human melanoma progression and consequences of gelatinase B overexpression},
  author={John R Macdougall and Maria Rosa Bani and Yulia Lin and Ruth J. Muschel and Robert S. Kerbel},
  booktitle={British Journal of Cancer},
  year={1999}
}
SummaryAlthough it is generally accepted that proteolytic degradation is an important mechanism used by malignant cells in the process of metastasis, comparatively little is known about the regulation of molecules responsible for proteolysis and how they become de-regulated during human tumour progression. Using a genetically related pair of human melanoma cell lines, derived from the same patient at different stages of disease, we analysed differences in the cytokine-mediated regulation of… CONTINUE READING
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