‘One night’ sleep deprivation stimulates hippocampal neurogenesis

  title={‘One night’ sleep deprivation stimulates hippocampal neurogenesis},
  author={Gigliola Grassi Zucconi and Sabrina Cipriani and Ioanna Balgkouranidou and Roberto Scattoni},
  journal={Brain Research Bulletin},
Sleep and adult neurogenesis: implications for cognition and mood.
Evidence from correlation, deprivation, and stimulation studies that sleep may be among those factors that regulate hippocampal neurogenesis is critically examined, suggesting that sleep loss impairs hippocampal Neurogenesis by the presence of wake-dependent factors, rather than by the absence of sleep-specific processes.
Sleep deprivation induces differential morphological changes in the hippocampus and prefrontal cortex in young and old rats
Evaluating the effects of 24 h of total sleep deprivation on neuronal morphology of pyramidal neurons from Layer III of the prefrontal cortex and the dorsal hippocampal CA1 region finds no differences in total dendritic length and branching length in both analyzed regions after sleep deprivation.
Rapid eye movement sleep deprivation contributes to reduction of neurogenesis in the hippocampal dentate gyrus of the adult rat.
The present findings support a hypothesis that REM sleep-associated processes facilitate proliferation of granule cells in the adult hippocampal DG.
[Effects of sleep deprivation in hippocampal neurogenesis].
Recent findings that associate sleep deprivation with changes in hippocampal neurogenesis and cognitive processes are described and possible mechanisms implicated in this deterioration such as circadian rhythm, melatonin receptors, and growth factors are described.
Short-Term Sleep Deprivation Stimulates Hippocampal Neurogenesis in Rats Following Global Cerebral Ischemia/Reperfusion
Short-term SD, especially the GCIR+12hSD*3d-treated method, stimulates neurogenesis in the hippocampal dentate gyrus (DG) of rats that undergo GCIR, and BDNF may be an underlying mechanism in this process.
Detrimental role of prolonged sleep deprivation on adult neurogenesis
An overview on how rhythms and sleep cycles regulate hippocampal and subventricular zone neurogenesis is provided, discussing some potential underlying mechanisms and some insights on the effects of antidepressants and hypnotic drugs on adult Neurogenesis are provided.
Modulation of Adult Hippocampal Neurogenesis by Sleep: Impact on Mental Health
It is postulated that the effects of sleep on hippocampal-dependent functions may possibly be mediated by a change in adult hippocampal neurogenesis, which could provide a route to new treatments for cognitive impairments and psychiatric disorders.


Sleep deprivation suppresses neurogenesis in the adult hippocampus of rats
Sleep deprivation (SD) reduces neurogenesis in the DG by affecting both total proliferation and the percentage of cells expressing a mature neuronal phenotype, hypothesize that sleep provides anabolic or signaling support for proliferation and cell fate determination.
Sleep Deprivation Reduces Proliferation of Cells in the Dentate Gyrus of the Hippocampus in Rats
It is suggested that sleep deprivation reduces proliferation of cells in the DG of the dorsal hippocampus, which gives rise to progenitor cells, which have the potential to differentiate into neurons.
Sleep deprivation effects on growth factor expression in neonatal rats: a potential role for BDNF in the mediation of delta power.
It is concluded that cortical BDNF expression reflects the onset of adult sleep-homeostatic response, whereas the profile of expression of both growth factors suggests a trophic effect of mild sleep deprivation.
How sleep deprivation affects gene expression in the brain: a review of recent findings.
  • C. Cirelli
  • Biology, Psychology
    Journal of applied physiology
  • 2002
Although the characterization of the molecular correlates of behavioral states is not yet complete, it is already apparent that the transition from sleep to waking can affect basic cellular functions such as RNA and protein synthesis, neural plasticity, neurotransmission and metabolism.
Sleep restriction suppresses neurogenesis induced by hippocampus-dependent learning.
It is suggested that sleep loss altered behavioral strategies to those that do not depend on the hippocampus, concomitantly reversing the neurogenic effects of hippocampus-dependent learning.
Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus
Investigation of the effect of antidepressants on hippocampal neurogenesis in the adult rat using the thymidine analog bromodeoxyuridine (BrdU) as a marker for dividing cells demonstrates that chronic antidepressant treatment significantly increases the number of BrdU-labeled cells in the dentate gyrus and hilus of the hippocampus.
Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine
  • B. Czéh, T. Michaelis, E. Fuchs
  • Psychology, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2001
The effect of tianeptine, a modified tricyclic antidepressant, in the chronic psychosocial stress model of adult male tree shrews, a model with high validity for research on the pathophysiology of major depression, is investigated.
Cell Proliferation in Adult Hippocampus is Decreased by Inescapable Stress: Reversal by Fluoxetine Treatment
It is reported that exposure to avoidance testing, regardless of pre-exposure to IS, decreases cell proliferation in the hippocampus, extending previous studies demonstrating downregulation of neurogenesis by exposure to acute stressors.