‘Neuroleptic Malignant Syndrome’ Without Neuroleptics

@article{Brennan1988NeurolepticMS,
  title={‘Neuroleptic Malignant Syndrome’ Without Neuroleptics},
  author={Daniel Brennan and Michael P. Mac Manus and John Howe and James McLoughlin},
  journal={British Journal of Psychiatry},
  year={1988},
  volume={152},
  pages={578 - 579}
}
SIR: Depersonalisation/derealisation are common symptoms of anxiety and of affective disorder, and are not uncommon features of other psychiatric syn dromes. They are also common in various organic states (e.g. hypoglycaemia) and are frequently likened by patients to dreaming, which occurs at a time of demonstrable alteration in cerebral activity. Furthermore, these phenomena are disorders of per ception, which suggests some organic basis. Is it possible that depersonalisation/derealisation are… 
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References

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The neuroleptic malignant syndrome--a review.
  • W. GibbA. Lees
  • Medicine, Psychology
    The Quarterly journal of medicine
  • 1985
The neuroleptic malignant syndrome (NMS) is an uncommon disorder characterised by muscular stiffness and hyperthermia. It is caused by the administration of neuroleptics or by the acute withdrawal of
Neuroleptic malignant syndrome.
  • J. Levenson
  • Medicine, Psychology
    The American journal of psychiatry
  • 1985
TLDR
Demographic and clinical features, diagnosis, treatment, outcome, and pathophysiology are critically reviewed, and a new set of diagnostic criteria, incorporating physical signs and routine laboratory tests, is proposed.
Fatal hyperpyrexia after withdrawal of levodopa
TLDR
The rapid decrease in dopaminergic activity may have been important in causing the neuroleptic malignant syndrome in a patient affected with idiopathic Parkinson's disease and levodopa-induced dyskinesias.
Case report of neuroleptic malignant syndrome associated with withdrawal from amantadine.
TLDR
This case report of neuroleptic malignant syndrome following withdrawal of Neuroleptics and amantadine suggests that dopamine agonists should not be discontinued in hyperpyrexic patients at risk for this syndrome.
Hyperthermia after discontinuance of levodopa and bromocriptine therapy
TLDR
Impaired nigrostriatal, hypothalamic, and mesolimbic dopaminergic functions could be involved in pathogenesis and hyperthermia is described as a complication after discontinuance of antiparkinsonian treatment with levodopa/carbidopa and bromocriptine.
BENIGN TYPE OF MALIGNANT SYNDROME
Levodopa withdrawal syndrome identical to neuroleptic malignant syndrome.
TLDR
It is proposed that NMS may be caused by levodopa withdrawal in Parkinson's disease, and that it is withdrawal of dopaminergic drive that causes the syndrome.