‘Glocal’ Robustness Analysis and Model Discrimination for Circadian Oscillators

@inproceedings{Hafner2009GlocalRA,
  title={‘Glocal’ Robustness Analysis and Model Discrimination for Circadian Oscillators},
  author={Marc Hafner and Heinz Koeppl and Martin Hasler and Andreas Wagner},
  booktitle={PLoS Computational Biology},
  year={2009}
}
To characterize the behavior and robustness of cellular circuits with many unknown parameters is a major challenge for systems biology. Its difficulty rises exponentially with the number of circuit components. We here propose a novel analysis method to meet this challenge. Our method identifies the region of a high-dimensional parameter space where a circuit displays an experimentally observed behavior. It does so via a Monte Carlo approach guided by principal component analysis, in order to… CONTINUE READING

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