‘Designer Drugs’

  title={‘Designer Drugs’},
  author={James F. Buchanan and C. R. Brown},
  journal={Medical Toxicology and Adverse Drug Experience},
Summary‘Designer drugs’ are substances intended for recreational use which are derivatives of approved drugs so as to circumvent existing legal restrictions. The term as popularised by the lay press lacks precision. Contrary to the popular belief that ‘designer drugs’ are original creations, the majority of these agents are ‘borrowed’ from legitimate pharmaceutical research. They merely represent the most recent developments in the evolution of mindaltering chemicals.The most extensively… 

Clinical Features and Management of Intoxication Due to Hallucinogenic Drugs

Hallucinogenic drugs are unique in that they produce the desired hallucinogenic effects at what are considered non-toxic doses and management of the intoxicated patient is dependent on the specific behavioural manifestation elicited by the drug.

Human Deaths and Toxic Reactions Attributed to MDMA and MDEA

MDMA and MDEA are synthetic amphetamine analogues that have received considerable media attention as recreational drugs popular among college students and young professionals and well-documented deaths related to the use of these two drugs are exceptionally rare.

Substance abuse: the designer drugs.

Sudden changes in mood, weight loss, depression, disturbed sleep patterns, deteriorating school or work performance, marital problems, and loss of interest in friends and social activities may be signs of drug addiction.

Neurochemical and behavioural characterisation of alkoxyamphetamine derivatives in rats

The present observations can enlighten the mechanisms of action of drugs showing a high risk for abuse among young populations, and suggest an impairment of releasable monoamine stores.

'Designer drugs'. Treating the damage caused by basement chemists.

Use of "designer drugs" has created a new dilemma for physicians, as toxicology laboratories cannot readily identify designer compounds, and physicians must rely on clinical presentation and treat accordingly.

Opioids and Other Analgesics

This chapter is concerned with those pain-killing drugs (analgesics) that are most likely to be misused, ranging from propoxyphene (Darvon) through the synthetic, opiatelike drugs to the major

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The aim of the present article is to provide a literature review on the health effects of stimulants as potential drugs of abuse, covering essentially cocaine, amphetamines and its derivatives, nicotine, caffeine and khat, and touch upon the issues of prescribed substances.

Drug abuse: newly-emerging drugs and trends.

  • G. Davis
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  • 2012

Identification of an acetal derivative of the piperonyl methyl ketone in tablets seized for suspected drug trafficking

Structural elucidation of a new chemical compound found in tablets seized in the Naples area (Italy) and manufactured in the Netherlands was conducted using nuclear magnetic resonance spectroscopy,



Potential misrepresentation of 3,4-methylenedioxyamphetamine (MDA). A toxicological warning.

The illicit synthesis of the popular drug 3,4-methylenedioxyamphetamine has frequently called upon the precursor piperonylacetone, which is reductively aminated with ammonium hydroxide, which could be mistaken for MDA if only simple presumptive tests are employed.

Pharmacologic investigation of compounds related to 3,4-methylenedioxyamphetamine (MDA).

HMDA differs qualitatively in actions from MDA and tends to be more toxic acutely for mice, and phenoxybenzamine supplemented a protective action of phenobarbital toward HMDA lethality.

The background and chemistry of MDMA.

  • A. Shulgin
  • Chemistry
    Journal of psychoactive drugs
  • 1986
Up to 1972, MDMA was entered with the phenethylamine exists in the literature representing the results of laboraname, and since then the heterocyclic term benzodioxole-5i tory studies and scientific experimentation with ethanamine has been the root name.

Methylenedioxyamphetamine. Clinical description of overdose, death, and review of pharmacology.

The patient's condition was initially stabilized and then deteriorated with uncontrollable hyperthermia, hematologic abnormalities, and coma that culminated in death, so phentolamine (Regitine) mesylate may be the preferred drug to be used in the treatment of future cases.

3,4-methylenedioxyamphetamine (MDA): analytical and forensic aspects of fatal poisoning.

  • G. Cimbura
  • Medicine
    Journal of forensic sciences
  • 1972
In spite of this tight control, MDA, known as the “love pill,” has apparently become popular in the drug oriented segment of the authors' society.

2,5-Dimethoxy-4-methyl-amphetamine (STP): A New Hallucinogenic Drug

2,5-Dimethoxy-4-methyl-amphetamine, the chemical present in the hallucinogenic drug STP, is about 100 times more potent as a hallucinogen than mescaline and only one-thirtieth as potent as lysergic acid diethylamide.

Can drugs be used to enhance the psychotherapeutic process?

Many preindustrial cultures traditionally use certain psychedelic plants to enhance a procedure that resembles psychotherapy--an idea that was also tested in Western psychiatry in the 1950s and

'Eve' and 'Ecstasy'. A report of five deaths associated with the use of MDEA and MDMA.

In three patients, MDMA or MDEA may have contributed to death by the induction of arrhythmias in individuals with underlying natural disease, and death as a consequence of the use of these drugs appears to be rare, but it does occur.

Identification of a new phencyclidine analog, 1-(1-phenylcyclohexyl)-4-methylpiperidine, as a drug of abuse.

A previously unreported phencyclidine (PCP) analog. 1-(1-phenylcyclohexyl)-4-methylpiperidine (I) in which the piperidine ring has been substituted with 4-methylpiperidine, has been observed to be an

Parkinsonism Induced By 1-Methyl-4-Phenyl-1, 2, 3, 6-Tetrahydropyridine (MPTP): Implications for Treatment and the Pathogenesis of Parkinson’s Disease

It is suggested that the occurrence of this full array of therapeutic complications in patients with MPTP-induced parkinsonism furthers the analogy between this syndrome and Parkinson’s disease.