‘Daunomycin’, a New Antibiotic of the Rhodomycin Group

  title={‘Daunomycin’, a New Antibiotic of the Rhodomycin Group},
  author={Aurelio di Marco and Marcello Gaetani and Piergiuseppe Orezzi and Biancamaria Scarpinato and Rosella Silvestrini and Mar{\'i}a Cristina Soldati and Teresa Dasdia and Lucia Valentini},
‘DAUNOMYCIN’ is a new antibiotic isolated from the cultures of S. peucetius1 in the Farmitalia Research Laboratories. The substance is easily obtained as hydrochloride in thin red needles melting at 184°–186° C, soluble in water, methanol, aqueous alcohols and insoluble in chloroform, ether, benzol. 

Daunomycin (Daunorubicin) and Adriamycin

Daunomycin (NSC-82151) is an antibiotic isolated from cultures of Streptomyces peucetius that exhibits marked cytotoxic activity against normal and neoplastic cells.

Antiviral Effect of Daunomycin

Although too toxic for routine systemic administration, local application of daunomycin for the treatment of herpetic or vaccinial keratitis might be possible, particularly if the infecting virus has become resistant to 5-iodo-2-deoxyuridine.

Mechanism of action of daunomycin.

  • A. Di Marco
  • Chemistry, Biology
    Acta geneticae medicae et gemellologiae
  • 1968
Daunomycin is a metabolite of Streptomyces peucetius which strongly inhibits a variety of experimental tumors and should be included in those antibiotics containing the tetrahydrotetracenquinone cromophore linked to a sugar.

Streptomycetes producing daunomycin and related compounds: Do we know enough about them after 25 years?

This review compares the features of production strains and their mutants and emphasizes the necessity of application of biochemical and biophysical analytical methods for better understanding these microorganisms and, above all, their further improving and practical usage.

Microbial conversion of anthracyclinones to carminomycins by a blocked mutant of Actinomadura roseoviolacea.

New anthracycline antibiotics were produced by a blocked mutant MuW1 of Actinomadura roseoviolacea from epsilon-pyrromycinone and aklavinone, respectively and it was found that the enzyme catalyzing hydroxylation at the C-11 position was not lost but was down regulated in the strainMuW1.

Bioconversion of the anthracycline analogue desacetyladriamycin by recombinant DoxA, a P450-monooxygenase from Streptomyces sp. strain C5.

[reaction: see text] A recombinant P450-monooxygenase, DoxA, obtained from Streptomyces sp. strain C5, the producer of the anticancer compound daunorubicin, was expressed in S. lividans TK24 and

Daunomycin and Related Antibiotics

Following Brockmann's suggestion (4963), those antibiotics that contained a tetrahydrotetracenquinone chromophore linked to a sugar should all be included in the anthracycline group.

Application of a Method Incorporating Treatment with Daunomycin for the Selective Isolation of Slower-Growing Fungi

A new simple method using an anthracycline antibiotic, daunomycin (DM), as a selection reagent in isolating slower-growing fungi was established, and the possibility of isolating rare fungus genera was increased when the DM method was employed.

Microbial conversion of anthracyclinones to daunomycin by blocked mutants of Streptomyces coeruleorubidus.

The biosynthetic pathway from epsilon-rhodomycinone to daunomycin was further confirmed by studying the bioconversion of anthracyclinones and anthRacyclines, which are presumed to be intermediates.

Anthracyclines and Anthracenediones

Daunorubicin was the first anthracycline isolated, a natural product isolated from the actinobacteria Streptomyces peucetius. It was identified in 1963 by both Italian and French groups [7, 38]. The



Über Actinomycetenfarbstoffe, VI. Pyrromycinone

Aus einem Streptomyces-Stamm wurden drei kristallisierte, als ν-, ζ-und ϵ-Pyrromycinon bezeichnete Farbstoffe isoliert. ν-Pyrromycinon ist ein 1.4.6-Trihydroxy-carbomethoxy-athyl-tetracenchinon, ζ-

Actinomycin D Inhibition of Deoxyribonucleic Acid-Dependent Synthesis of Ribonucleic Acid

Findings support the work of others on the mode of action of actinomycin D in vivo and can be reversed by adding deoxyribonucleic acid to the enzymatic reaction.

Stoffwechselprodukte von Actinomyceten, XVI. Cinerubine

Die von verschiedenen Streptomyces-Arten gleichzeitig gebildeten roten Antibiotica Cinerubin A und B geben bei der sauren Hydrolyse drei Zucker und ein Aglykon C22H20O9. Fur das letztere wurde auf

The mode of action of actinomycin D.

  • J. Kirk
  • Biology
    Biochimica et biophysica acta
  • 1960

On the inhibition of RNA synthesis by actinomycin.