‘Daunomycin’, a New Antibiotic of the Rhodomycin Group

@article{Marco1964DaunomycinAN,
  title={‘Daunomycin’, a New Antibiotic of the Rhodomycin Group},
  author={Aurelio di Marco and Marcello Gaetani and Piergiuseppe Orezzi and Biancamaria Scarpinato and Rosella Silvestrini and Mar{\'i}a Cristina Soldati and Teresa Dasdia and Lucia Valentini},
  journal={Nature},
  year={1964},
  volume={201},
  pages={706-707}
}
‘DAUNOMYCIN’ is a new antibiotic isolated from the cultures of S. peucetius1 in the Farmitalia Research Laboratories. The substance is easily obtained as hydrochloride in thin red needles melting at 184°–186° C, soluble in water, methanol, aqueous alcohols and insoluble in chloroform, ether, benzol. 
Daunomycin (Daunorubicin) and Adriamycin
TLDR
Daunomycin (NSC-82151) is an antibiotic isolated from cultures of Streptomyces peucetius that exhibits marked cytotoxic activity against normal and neoplastic cells.
Antiviral Effect of Daunomycin
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Following Brockmann's suggestion (4963), those antibiotics that contained a tetrahydrotetracenquinone chromophore linked to a sugar should all be included in the anthracycline group.
Application of a Method Incorporating Treatment with Daunomycin for the Selective Isolation of Slower-Growing Fungi
TLDR
A new simple method using an anthracycline antibiotic, daunomycin (DM), as a selection reagent in isolating slower-growing fungi was established, and the possibility of isolating rare fungus genera was increased when the DM method was employed.
Microbial conversion of anthracyclinones to daunomycin by blocked mutants of Streptomyces coeruleorubidus.
TLDR
The biosynthetic pathway from epsilon-rhodomycinone to daunomycin was further confirmed by studying the bioconversion of anthracyclinones and anthRacyclines, which are presumed to be intermediates.
Microbial conversion of anthracycline antibiotics.
pathway was elucidated by YosHIMOro et al.2) from an analysis of the structures of anthracyclines produced during microbial conversion of a presumptive intermediate, aklavinone, by the
Stereochemistry of intercalation: interaction of daunomycin with DNA.
TLDR
Daunomycin, a glycosidic anthracycline antibiotic from Streptomyces peucetius, is being used in the treatment of acute leukaemia and solid tumours in man due to complex formation with the DNA of deoxyribonucleoprotein4.
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    Biochimica et biophysica acta
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