‘ Midget ’, a new dwarfing gene in the house mouse dependant on a genetic background of small body size for its expression

@article{Fowler1961M,
  title={‘ Midget ’, a new dwarfing gene in the house mouse dependant on a genetic background of small body size for its expression},
  author={Ruth E. Fowler and Robert Geoffrey Edwards},
  journal={Genetics Research},
  year={1961},
  volume={2},
  pages={272-282}
}
Midget , a new dwarfing gene in the house mouse, was found in a line ( NS ) selected for small body size. Backcrosses to, and heterozygous matings of NS mice gave midget offspring in the expected 1:1 and 1:3 ratios. Backcrosses to two other lines of mice selected for small body size resulted in fewer midget offspring than expected and in a reduced phenotypic expression of the gene, though matings between these midget offspring gave all midget progeny. A characteristic check in growth occurred… Expand

Figures and Tables from this paper

The size and endocrine activity of the pituitary in mice selected for large or small body-size
TLDR
Adult mice of strain N were used in studies of pituitary weights, gonadotrophic activity of the anterior pituitsary, thyroid activity, and alterations in growth rates following the injection of growth hormone. Expand
Forging links between population and quantitative genetics
TLDR
An experimental evaluation of a rare allele of large effect (smlab) detected in a sample of the Canberra outbred population of Drosophila melanogaster provides experimental corroboration of the links between population genetics and quantitative genetics. Expand
A method to detect large influences of specific sex chromosomes on quantitative traits
TLDR
The heterogametic sex of crosses between two highly inbred lines of animals provides a simple means to detect large effects of specific sex chromosomes on quantitative traits, suggesting a sizable amount of epistasis (interaction between sex chromosomes and genetic background). Expand
Combining Molecular and Quantitative Genetics: Decomposing the Architecture of Lifespan Development
TLDR
Recent advances in molecular genetics are making possible the examination of the influence of individual genetic loci in the hitherto anonymous polygenic sets of quantitative investigations, offering unprecedented opportunities both for enhanced reductionist approaches that elucidate the molecular basis of the genetic influence and for integrationist approach that explore the dynamics of individuated genetic and environmental factors in complex developing systems. Expand
Animal models--a neglected medical resource.
TLDR
The vast wealth of this neglected medical resource can be used to advantage only if new, co-ordinated interprofessional efforts are initiated between human and veterinary medical centers in collaboration with the . Expand

References

SHOWING 1-10 OF 18 REFERENCES
Genetics of Body Size and Related Characters. I. Selecting Small and Large Races of the Laboratory Mouse
TLDR
Data agree with the view that size genes or modifiers multiply each other's effects (that is, act geometrically), and do not simply add to or subtract from the body weight some definite and constant number of grams. Expand
Genetics of Body Size and Related Characters. II. Satellite Characters Associated with Body Size in Mice
TLDR
Differences between the mouse races in litter size or length of appendages are determined, not by special fertility factors or ear-length genes, etc., but, in great part at least, by the same common and general multiple size or growth rate factors that control body size. Expand
Selection of mice for growth on high and low planes of nutrition
TLDR
Two-way selection was applied to the growth of mice between 3 and 6 weeks of age when rearing on a high plane of nutrition and, in another pair of lines, when reared on a low plane ofnutrition, and the conclusions drawn are summarized at the beginning of the Discussion. Expand
A STUDY OF NATURAL GROWTH AND OSSIFICATION IN HEREDITARY DWARF MICE1
TLDR
Hereditary dwarfism in mice has interested geneticists and endocrinologists since 1929, and it was reported that feeding desiccated thyroid resulted in marked gains in body weight but abnormal growth (fatty subcutaneous and intraperitoneal deposits). Expand
Conception in Prepuberal Mice following Artificially Induced Ovulation and Mating
TLDR
Experimental results have indicated that, after fertilization, these ova approximate to the viability of ova from spontaneous ovulations in prepuberal mice. Expand
Anterior pituitary cytology of the dwarf mouse
Induction of superovulation and pregnancy
  • 1957
Induction of superovulation and pregnancy in mature mice by gonadotrophins.
...
1
2
...