‘‘70th Birthday Professor Riederer’’ Induction of glial cell line-derived and brain-derived neurotrophic factors by rasagiline and (−)deprenyl: a way to a disease-modifying therapy?

@article{Maruyama201270thBP,
  title={‘‘70th Birthday Professor Riederer’’ Induction of glial cell line-derived and brain-derived neurotrophic factors by rasagiline and (−)deprenyl: a way to a disease-modifying therapy?},
  author={Wakako Maruyama and Makoto Naoi},
  journal={Journal of Neural Transmission},
  year={2012},
  volume={120},
  pages={83-89}
}
Neuroprotection has been proposed in neurodegenerative disorders, such as Parkinson’s and Alzheimer’s diseases, to delay or halt disease progression or reverse neuronal deterioration. The inhibitors of type B monoamine oxidase (MAO), rasagiline and (−)deprenyl, prevent neuronal loss in cellular and animal models of neurodegenerative disorders by intervening in the death signal pathway in mitochondria. In addition, rasagiline and (−)deprenyl increase the expression of anti-apoptotic Bcl-2… CONTINUE READING