ω-3 fatty acids as an adjuvant therapy ameliorates methotrexate-induced hepatotoxicity in children and adolescents with acute lymphoblastic leukemia: A randomized placebo-controlled study.

@article{Elbarbary20163FA,
  title={ω-3 fatty acids as an adjuvant therapy ameliorates methotrexate-induced hepatotoxicity in children and adolescents with acute lymphoblastic leukemia: A randomized placebo-controlled study.},
  author={Nancy Samir Elbarbary and Eman Abdel Rahman Ismail and Reham Kamel Farahat and Manal H El-Hamamsy},
  journal={Nutrition},
  year={2016},
  volume={32 1},
  pages={41-7}
}
OBJECTIVES Methotrexate (MTX)-induced hepatotoxicity is a significant clinical problem that may affect overall prognosis and disease outcome. Oxidative stress is a key player in its pathogenesis. The aim of this study was to investigate the role of ω-3 fatty acids as an adjuvant therapy in children and adolescents with acute lymphoblastic leukemia (ALL) during the maintenance phase of chemotherapy and the effect of ω-3 on MTX-induced hepatotoxicity. METHODS This randomized, double-blind… CONTINUE READING