σ1 receptors activate astrocytes via p38 MAPK phosphorylation leading to the development of mechanical allodynia in a mouse model of neuropathic pain.

@article{Moon20141RA,
  title={σ1 receptors activate astrocytes via p38 MAPK phosphorylation leading to the development of mechanical allodynia in a mouse model of neuropathic pain.},
  author={J Y Moon and Dae Hyun Roh and Sun Young Yoon and S R Choi and S G Kwon and Hong Seok Choi and So Yeon Kang and Ho Jae Han and A J Beitz and Shin Bi Oh and Jeong Hoon Lee},
  journal={British journal of pharmacology},
  year={2014},
  volume={171 24},
  pages={5881-97}
}
BACKGROUND AND PURPOSE Spinal astrocytes have emerged as important mechanistic contributors to the genesis of mechanical allodynia (MA) in neuropathic pain. We recently demonstrated that the spinal sigma non-opioid intracellular receptor 1 (σ1 receptor) modulates p38 MAPK phosphorylation (p-p38), which plays a critical role in the induction of MA in neuropathic rats. However, the histological and physiological relationships among σ1, p-p38 and astrocyte activation is unclear. EXPERIMENTAL… CONTINUE READING
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