σ-1 Receptor Ligands

@article{Hayashi20041RL,
  title={$\sigma$-1 Receptor Ligands},
  author={Teruo Hayashi and Tsung-Ping Su},
  journal={CNS Drugs},
  year={2004},
  volume={18},
  pages={269-284}
}
The σ receptor was originally proposed to be a subtype of the opioid receptor. However, it is now clear that σ receptors are unique non-opioid, non-phencyclidine brain proteins. Two types of σ receptor exist, the σ-1 receptor and the σ-2 receptor. σ-1 receptors have been cloned and their distribution, physiological functions and roles in signal transduction were recently characterised. Certain sex hormones in the brain (neurosteroids) are known to interact with σ-1 receptors. σ-1 receptors… Expand
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TLDR
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TLDR
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TLDR
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TLDR
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