κ-opioid receptors are implicated in the increased potency of intra-accumbens nalmefene in ethanol-dependent rats

@article{Nealey2011opioidRA,
  title={$\kappa$-opioid receptors are implicated in the increased potency of intra-accumbens nalmefene in ethanol-dependent rats},
  author={Kathryn A. Nealey and Alexander W. Smith and Seth M Davis and Daniel G. Smith and B. Walker},
  journal={Neuropharmacology},
  year={2011},
  volume={61},
  pages={35-42}
}
Previously, it was shown that ethanol-dependent animals display increased sensitivity to the general opioid receptor antagonist nalmefene compared to naltrexone. It was hypothesized that the dissociable effects of the two antagonists were attributable to a κ-opioid receptor mechanism. Nucleus accumbens dynorphin is upregulated following chronic ethanol exposure and such neuroadaptations could contribute to nalmefene's increased potency in ethanol-dependent animals. To test this hypothesis, male… Expand
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