κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction.

@article{Butelman2012opioidRS,
  title={κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction.},
  author={Eduardo Roque Butelman and Vadim Yuferov and Mary Jeanne Kreek},
  journal={Trends in neurosciences},
  year={2012},
  volume={35 10},
  pages={587-96}
}
Addictions to cocaine or heroin/prescription opioids [short-acting μ-opioid receptor (MOPr) agonists] involve relapsing cycles, with experimentation/escalating use, withdrawal/abstinence, and relapse/re-escalation. κ-Opioid receptors (KOPr; encoded by OPRK1), and their endogenous agonists, the dynorphins (encoded by PDYN), have counter-modulatory effects on reward caused by cocaine or MOPr agonist exposure, and exhibit plasticity in addictive-like states. KOPr/dynorphin activation is implicated… CONTINUE READING
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