"η6"-Type anion-π in biomolecular recognition.

Abstract

Theoretical and compelling experimental evidence indicates that the interaction between an anion and an aromatic π system when the anion is directly above the ring face ("η(6)"-type anion-π), can be attractive. This may play an important role in the formation and recognition of biomolecular structures. We examined high-resolution structures of proteins and nucleic acids for the presence of "η(6)"-type anion-π. Though less frequent than its counterpart cation-π, "η(6)"-type anion-π is observed unambiguously, occurring in protein/nucleic acid loops and often involving conserved/coevolving sites in proteins, suggesting it plays an important role in macromolecular folding and function.

DOI: 10.1016/j.febslet.2012.10.017

Cite this paper

@article{Chakravarty20126TypeAI, title={"η6"-Type anion-π in biomolecular recognition.}, author={Suvobrata Chakravarty and Zi-Zhang Sheng and Bradley E Iverson and Brian Moore}, journal={FEBS letters}, year={2012}, volume={586 23}, pages={4180-5} }