γH2AX: a sensitive molecular marker of DNA damage and repair

@article{Mah2010H2AXAS,
  title={γH2AX: a sensitive molecular marker of DNA damage and repair},
  author={L-J Mah and Assam El-Osta and Tom C. Karagiannis},
  journal={Leukemia},
  year={2010},
  volume={24},
  pages={679-686}
}
Phosphorylation of the Ser-139 residue of the histone variant H2AX, forming γH2AX, is an early cellular response to the induction of DNA double-strand breaks. Detection of this phosphorylation event has emerged as a highly specific and sensitive molecular marker for monitoring DNA damage initiation and resolution. Further, analysis of γH2AX foci has numerous other applications including, but not limited to, cancer and aging research. Quantitation of γH2AX foci has also been applied as a useful… CONTINUE READING
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